The Houston Methodist Research Institute, Houston, TX 77030, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA; The University of Texas, M.D. Anderson Cancer Center, Department of Genetics, Houston, TX, USA.
The Houston Methodist Research Institute, Houston, TX 77030, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA.
Cell Immunol. 2021 Feb;360:104259. doi: 10.1016/j.cellimm.2020.104259. Epub 2020 Dec 16.
Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.
维生素 D 调节体内平衡、抗微生物反应和炎症。维生素 D 受体在巨噬细胞和其他免疫细胞中表达，调节许多不同基因的转录，包括编码抗微生物肽的基因。SARS-CoV-2 感染最严重的并发症之一是由肺巨噬细胞的过度炎症反应（通常称为细胞因子风暴）引起的急性呼吸窘迫综合征（ARDS）。研究表明，维生素 D 缺乏会增加 COVID-19 感染中 ARDS 的严重程度。我们在这里讨论维生素 D 补充如何影响巨噬细胞和髓源抑制细胞（MDSCs）的炎症反应，抑制过度炎症反应，并减轻 COVID-19 患者的 ARDS。
