Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou 310058, China; College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou 310058, China.
J Hazard Mater. 2021 Apr 5;407:124876. doi: 10.1016/j.jhazmat.2020.124876. Epub 2020 Dec 16.
Simultaneous exposure to multiple pollutants has received great concerns considering that the interactions between pollutants can alter the environment fate and bioavailability of pollutants with potentially deleterious effects. Graphene oxide (GO) has been widely used in many areas including environmental remediation, biology and agriculture. However, researchers have largely ignored the combined toxicity of GO with coexisting toxicants. Cis-bifenthrin (cis-BF), a typical synthetic pyrethroid insecticide, was frequently detected in the environment, which raised the possibility of interaction between cis-BF and GO. Our study investigated the toxic effects of cis-BF alone or combined with GO on the lipid homeostasis in Xenopus laevis. Tadpoles at 51 stage were exposed to cis-BF (0, 12, 60 and 300 ng/L) or in their combination with GO (0.1 mg/L) for 21 days. Coexposure to cis-BF and GO deteriorated the lipid homeostasis disruption in tadpoles. The up- or down-regulation of lipogenesis genes expression and enzymes activity were amplified in the coexposure groups. Furthermore, the presence of GO enhanced the deleterious impacts of cis-BF on the hepatic function in tadpoles. This study uniquely shows that GO promotes the lipotoxicity and hepatic function deficit caused by cis-BF exposure in frog.
同时暴露于多种污染物引起了广泛关注，因为污染物之间的相互作用可能会改变污染物的环境归宿和生物可利用性，从而产生潜在的有害影响。氧化石墨烯（GO）已广泛应用于许多领域，包括环境修复、生物学和农业。然而，研究人员在很大程度上忽略了 GO 与共存有毒物质的联合毒性。顺式氯氟氰菊酯（cis-BF）是一种典型的合成拟除虫菊酯类杀虫剂，经常在环境中检测到，这增加了 cis-BF 与 GO 相互作用的可能性。本研究调查了 cis-BF 单独或与 GO 联合暴露对非洲爪蟾（Xenopus laevis）脂质稳态的毒性影响。51 期的蝌蚪分别暴露于 cis-BF（0、12、60 和 300ng/L）或与 GO（0.1mg/L）联合暴露 21 天。cis-BF 和 GO 的共同暴露加剧了蝌蚪脂质稳态的破坏。在共同暴露组中，脂肪生成基因表达和酶活性的上调或下调被放大。此外，GO 的存在增强了 cis-BF 对蝌蚪肝功能的有害影响。本研究首次表明，GO 促进了 cis-BF 暴露引起的青蛙脂质毒性和肝功能缺陷。
