Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP) - CONICET (CCT La Plata), Calle 47 y 115, (B1900AJI), La Plata, Buenos Aires, Argentina.
Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP) - CONICET (CCT La Plata), Calle 47 y 115, (B1900AJI), La Plata, Buenos Aires, Argentina; Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC), Partner Laboratory of the Max Planck Institute for Biophysical Chemistry (MPIbpC, MPG), Centro de Estudios Interdisciplinarios (CEI), Universidad Nacional de Rosario, Maipú 1065, S2000 Rosario, Santa Fe, Argentina.
Bioresour Technol. 2021 Feb;322:124546. doi: 10.1016/j.biortech.2020.124546. Epub 2020 Dec 16.
Enzymes exhibit a tremendous potential due to the catalytic activity in response to physiological conditions and specific microenvironments. Exploiting these properties in combination with the versatility of biopolymers, a fascinating field for the rational development of a new class of "smart" delivery systems for therapeutic molecules is proposed. Many strategies have been recently developed to produce matrices with the desirable properties of molecular release, and enzymes could be playing a relevant role in modify the chemical composition of the polymers, the porosity and surface area of the matrices and modulate the kinetic of controlled release. Enzyme based computational systems have appeared as a relevant complementary tool to design novel smart bioactive matrices for programmable drug delivery. The present review is reporting the recent advances and projections of smart biopolymeric matrices activated by enzymes for sustained release of therapeutic molecules, highlighting various applications in the area of advanced drug delivery.
酶由于其在生理条件和特定微环境下的催化活性，显示出巨大的潜力。利用这些特性并结合生物聚合物的多功能性，可以为治疗分子的新型“智能”递药系统的合理开发提出一个引人入胜的领域。最近已经开发出许多策略来生产具有所需分子释放特性的基质，而酶可能在改变聚合物的化学组成、基质的孔隙率和表面积以及调节控制释放的动力学方面发挥相关作用。基于酶的计算系统已成为设计用于可编程药物输送的新型智能生物活性基质的相关互补工具。本综述报告了酶激活的智能生物聚合物基质在治疗分子的持续释放方面的最新进展和预测，强调了在高级药物输送领域的各种应用。
