Institute of Research and Development, Duy Tan University, Da Nang City 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 1A TL29, District 12, Hochiminh City 700000, Viet Nam.
Biomedical Engineering Department, International University, National Universities in HCMC, HCMC 70000, Viet Nam.
Mater Sci Eng C Mater Biol Appl. 2018 Nov 1;92:1016-1030. doi: 10.1016/j.msec.2018.02.006. Epub 2018 Feb 9.
Studies on "smart" polymeric material performing environmental stimuli such as temperature, pH, magnetic field, enzyme and photo-sensation have recently paid much attention to practical applications. Among of them, thermo-responsive grafted copolymers, amphiphilic steroids as well as polyester molecules have been utilized in the fabrication of several multifunctional platforms. Indeed, they performed a strikingly functional improvement comparing to some original materials and exhibited a holistic approach for biomedical applications. In case of drug delivery systems (DDS), there has been some successful proof of thermal-responsive grafted platforms on clinical trials such as ThermoDox®, BIND-014, Cynviloq IG-001, Genexol-PM, etc. This review would detail the recent progress and highlights of some temperature-responsive polymer-grafted nanomaterials or hydrogels in the 'smart' DDS that covered from synthetic polymers to nature-driven biomaterials and novel generations of some amphiphilic functional platforms. These approaches could produce several types of smart biomaterials for human health care in future.
目前，人们对能对环境刺激（如温度、pH 值、磁场、酶和光）做出响应的“智能”聚合物材料的研究引起了人们的广泛关注，这些刺激响应性聚合物材料具有广泛的潜在应用价值。其中，温敏接枝共聚物、两亲性甾体以及聚酯分子已被用于构建多种多功能平台。事实上，与一些原始材料相比，这些材料的性能得到了显著提高，并为生物医学应用提供了整体解决方案。以药物传递系统（DDS）为例，一些温敏接枝平台已经在临床试验中得到了成功验证，如 ThermoDox®、BIND-014、Cynviloq IG-001、Genexol-PM 等。本综述详细介绍了近年来一些温度响应性聚合物接枝纳米材料或水凝胶在“智能”DDS 中的最新进展和亮点，涵盖了从合成聚合物到天然驱动的生物材料以及一些两亲性功能平台的新一代材料。这些方法为未来的人类医疗保健提供了多种类型的智能生物材料。
