A fast technique for hyper-echoic region separation from brain ultrasound images using patch based thresholding and cubic B-spline based contour smoothing.

Ultrasound image guided brain surgery (UGBS) requires an automatic and fast image segmentation method. The level-set and active contour based algorithms have been found to be useful for obtaining topology-independent boundaries between different image regions. But slow convergence limits their use in online US image segmentation. The performance of these algorithms deteriorates on US images because of the intensity inhomogeneity. This paper proposes an effective region-driven method for the segmentation of hyper-echoic (HE) regions suppressing the hypo-echoic and anechoic regions in brain US images. An automatic threshold estimation scheme is developed with a modified Niblack's approach. The separation of the hyper-echoic and non-hyper-echoic (NHE) regions is performed by successively applying patch based intensity thresholding and boundary smoothing. First, a patch based segmentation is performed, which separates roughly the two regions. The patch based approach in this process reduces the effect of intensity heterogeneity within an HE region. An iterative boundary correction step with reducing patch size improves further the regional topology and refines the boundary regions. For avoiding the slope and curvature discontinuities and obtaining distinct boundaries between HE and NHE regions, a cubic B-spline model of curve smoothing is applied. The proposed method is 50-100 times faster than the other level-set based image segmentation algorithms. The segmentation performance and the convergence speed of the proposed method are compared with four other competing level-set based algorithms. The computational results show that the proposed segmentation approach outperforms other level-set based techniques both subjectively and objectively.