Chen Chao, Ge Xiaoxu, Zhao Yamei, Wang Da, Ling Limian, Zheng Shu, Ding Kefeng, Wang Jian, Sun Lifeng
Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2020 Dec 10;10:605349. doi: 10.3389/fonc.2020.605349. eCollection 2020.
Reports indicate that most metastatic ovarian cancer (MOC) originates from gastrointestinal cancer (GIC). Notably, GICs metastasize to the ovary frequently 3 main routes including hematogenous spread, lymphogenous spread, and transcoelomic spread. Nonetheless, the mechanism of the progression remains unknown, and only a handful of literature exists on the molecular alteration implicated in MOC from GIC. This work collected existing evidence and literature on the vital molecules of the metastatic pathway and systematically analyzed them geared toward exploring the mechanism of the metastatic pathway of MOC. Further, this review described dominating molecular alteration in the metastatic process from cancer cells detaching away from lesions to arrive at the ovary, including factors for regulating signaling pathways in epithelial-interstitial transformation, invading, and surviving in the circulatory system or abdominal cavity. We interrogated the basis of the ovary as a distant metastatic site. This article provides new insights into the metastatic pathway and generates novel therapeutic targets for effective treatment and satisfactory outcomes in GIC patients.
报告表明，大多数转移性卵巢癌（MOC）起源于胃肠道癌（GIC）。值得注意的是，GICs常通过3种主要途径转移至卵巢，包括血行播散、淋巴道播散和种植性播散。尽管如此，其进展机制仍不清楚，关于GIC来源的MOC相关分子改变的文献也寥寥无几。本研究收集了关于转移途径关键分子的现有证据和文献，并对其进行系统分析，以探索MOC转移途径的机制。此外，本综述描述了癌细胞从原发灶脱离并转移至卵巢这一过程中的主要分子改变，包括上皮-间质转化、侵袭以及在循环系统或腹腔中存活等信号通路的调控因子。我们探究了卵巢作为远处转移部位的基础。本文为转移途径提供了新的见解，并为GIC患者的有效治疗和满意预后产生了新的治疗靶点。
