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伴有高钙血症和BRAF突变的复发性成釉细胞瘤：一例报告

Recurrent ameloblastoma with both hypercalcemia and BRAF mutation: A case report.

作者信息

Suzuki Hidenori, Sasaki Eiichi, Nakamura Ryota, Sawabe Michi, Hagiwara Sumitaka, Hyodo Ikuo, Hanai Nobuhiro

机构信息

Department of Head and Neck Surgery Aichi Cancer Center Hospital Nagoya Japan.

Department of Pathology and Molecular Diagnostics Aichi Cancer Center Hospital Nagoya Japan.

出版信息

Clin Case Rep. 2020 Oct 28;8(12):3463-3467. doi: 10.1002/ccr3.3443. eCollection 2020 Dec.

DOI:10.1002/ccr3.3443
PMID:33363952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7752588/
Abstract

This case report describes a mandibular ameloblastoma with both V600E mutation and rare hypercalcemia. The patient without distant metastasis underwent subtotal mandibulectomy using double flaps of fibula and anterolateral thigh. A whole body computed tomography scan taken 69 months after surgery revealed neither recurrence nor metastasis.

摘要

本病例报告描述了一例同时具有V600E突变和罕见高钙血症的下颌骨成釉细胞瘤。该患者无远处转移，接受了腓骨和股前外侧双皮瓣下颌骨次全切除术。术后69个月进行的全身计算机断层扫描显示既无复发也无转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/202577aca137/CCR3-8-3463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/8d52648d3f6b/CCR3-8-3463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/31930ffc5924/CCR3-8-3463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/628b6fc2265d/CCR3-8-3463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/b6cfdc9500a8/CCR3-8-3463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/202577aca137/CCR3-8-3463-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/8d52648d3f6b/CCR3-8-3463-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/31930ffc5924/CCR3-8-3463-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/628b6fc2265d/CCR3-8-3463-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/b6cfdc9500a8/CCR3-8-3463-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1723/7752588/202577aca137/CCR3-8-3463-g005.jpg

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J Oral Pathol Med. 2020 Nov;49(10):1061-1067. doi: 10.1111/jop.13081. Epub 2020 Jul 18.
2
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review.B-raf原癌基因丝氨酸/苏氨酸激酶V600E突变的成釉细胞瘤靶向治疗的当前概念：系统评价
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[A Case of Malignant Ameloblastoma Associated with Uncontrollable Hypercalcemia].
[一例伴难以控制的高钙血症的恶性成釉细胞瘤病例]
Gan To Kagaku Ryoho. 2019 May;46(Suppl 1):55-56.
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Hypercalcemia of Malignancy.恶性肿瘤高钙血症
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Clinical benefit and radiological response with BRAF inhibitor in a patient with recurrent ameloblastoma harboring V600E mutation.携带 V600E 突变的复发性成釉细胞瘤患者中 BRAF 抑制剂的临床获益和放射学反应。
BMC Cancer. 2018 Sep 12;18(1):887. doi: 10.1186/s12885-018-4802-y.
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Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients.中国多发性骨髓瘤患者 BRAF V600E 突变的流行率和临床病理意义。
Clin Lymphoma Myeloma Leuk. 2018 Jul;18(7):e315-e325. doi: 10.1016/j.clml.2018.05.008. Epub 2018 May 15.
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Expression of parathyroid hormone related protein (PTHRP) in ameloblastomas.甲状旁腺激素相关蛋白（PTHRP）在成釉细胞瘤中的表达。
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BRAF-V600E expression correlates with ameloblastoma aggressiveness.BRAF-V600E表达与成釉细胞瘤的侵袭性相关。
Histopathology. 2017 Feb;70(3):473-484. doi: 10.1111/his.13095. Epub 2016 Nov 23.
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