Birnbaum G, Aubitz S, Kotilinek L
Department of Neurology, University of Minnesota, School of Medicine, Minneapolis 55455.
Neurology. 1988 Jan;38(1):28-30. doi: 10.1212/wnl.38.1.28.
Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In view of these findings, we undertook a systematic search for autonomously proliferating cells in the spinal fluids of MS patients and those with other neurologic diseases (OND). In vivo activated blast cells were isolated from the CSF of six MS patients and six OND controls. A total of 442 clones were grown from these cells and assayed for their ability to proliferate independently, without the need for T cell-produced lymphokines. No autonomously proliferating clones were detected. Thus, while our data do not exclude the possibility that HTLV I transformed cells may exist in the CSF of MS patients, they do suggest that such cells are exceptional.
最近发表的报告表明，多发性硬化症（MS）可能与人类逆转录病毒感染有关。确实，从一名MS患者的脑脊液中分离出了一个自主增殖的T细胞克隆，这一观察结果被解释为表明感染了人类嗜T淋巴细胞病毒I（HTLV I）。鉴于这些发现，我们对MS患者和其他神经系统疾病（OND）患者的脑脊液中的自主增殖细胞进行了系统搜索。从6名MS患者和6名OND对照的脑脊液中分离出了体内活化的母细胞。从这些细胞中总共培养出442个克隆，并检测它们独立增殖的能力，而无需T细胞产生的淋巴因子。未检测到自主增殖的克隆。因此，虽然我们的数据不排除HTLV I转化细胞可能存在于MS患者脑脊液中的可能性，但确实表明此类细胞是罕见的。
