Kölmel H W, Sudau C
Department of Neurology, Klinikum Rudolf-Virchow, Standort Charlottenburg, Berlin, F.R.G.
J Neuroimmunol. 1988 Dec;20(2-3):229-32. doi: 10.1016/0165-5728(88)90164-6.
The absolute numbers and ratios of helper/inducer (T4) and cytotoxic/suppressor (T8) T-cells were determined in cerebrospinal fluid (CSF) and blood of patients with multiple sclerosis (MS) and various other neurologic diseases (OND). In patients with MS, the T4:T8 ratio was higher in both blood and CSF, and the increase was significantly greater in CSF than in blood. These findings were due to an increased proportion of T4-lymphocytes in the CSF and to a decreased proportion of T8-cells in blood. These results indicate the need for additional studies of CSF lymphocytes in patients with MS.
在患有多发性硬化症（MS）以及各种其他神经系统疾病（OND）的患者的脑脊液（CSF）和血液中，测定了辅助/诱导型（T4）和细胞毒性/抑制型（T8）T细胞的绝对数量和比例。在MS患者中，血液和脑脊液中的T4:T8比值均较高，且脑脊液中的升高幅度明显大于血液中的升高幅度。这些发现是由于脑脊液中T4淋巴细胞比例增加以及血液中T8细胞比例降低所致。这些结果表明需要对MS患者的脑脊液淋巴细胞进行更多研究。
