阿尔茨海默病年龄谱中的新皮质形态学、病变计数及胆碱乙酰转移酶水平

Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease.

作者信息

Hansen L A, DeTeresa R, Davies P, Terry R D

机构信息

Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla 92093.

出版信息

Neurology. 1988 Jan;38(1):48-54. doi: 10.1212/wnl.38.1.48.

DOI:10.1212/wnl.38.1.48

PMID:3336463

Abstract

We studied neocortical morphometry (cortical thickness, neurons, and glia), lesion counts (plaques and tangles), and choline acetyltransferase levels in up to 113 Alzheimer brains and 48 controls. Comparisons between young (under 65) and old (over 70) Alzheimer cases revealed more tangles in the former, but no other statistically significant differences in the measured variables. Differences in these parameters between young Alzheimer cases and young controls were similar to the differences found between old Alzheimer cases and old controls. Linear regression analyses correlating some of these variables with age in Alzheimer's disease, considered together with the effects of normal aging on the same parameters, reveal in Alzheimer's disease a spectrum of graded pathologic severity inversely proportional to age. Nevertheless, even in advanced old age (80 to 100), significant differences persist in these parameters between very elderly Alzheimer brains and controls.

摘要

我们研究了多达113例阿尔茨海默病患者大脑和48例对照者的新皮质形态学（皮质厚度、神经元和胶质细胞）、病变计数（斑块和缠结）以及胆碱乙酰转移酶水平。对年轻（65岁以下）和老年（70岁以上）阿尔茨海默病病例进行比较发现，前者的缠结更多，但在测量变量方面没有其他统计学上的显著差异。年轻阿尔茨海默病病例与年轻对照者之间这些参数的差异，与老年阿尔茨海默病病例与老年对照者之间的差异相似。将阿尔茨海默病中这些变量中的一些与年龄进行线性回归分析，并结合正常衰老对相同参数的影响，结果显示在阿尔茨海默病中存在一系列分级的病理严重程度，与年龄成反比。然而，即使在高龄（80至100岁）时，非常年老的阿尔茨海默病患者大脑与对照者在这些参数上仍存在显著差异。