Foster T C, Jacobson J D, Valenzuela G J
Department of Obstetrics and Gynecology, San Bernardino County Medical Center, California.
Obstet Gynecol. 1988 Feb;71(2):147-9.
Two different regimens for oxytocin augmentation of labor were compared retrospectively in two institutions. In one regimen, the interval between dose increments was 15 minutes; in the other it was 30 minutes. All study patients were nulliparous and had uncomplicated pregnancies in spontaneous active labor; the 15-minute group consisted of 92 patients and the 30-minute group had 82 patients. No differences were demonstrated in age, dilation when oxytocin administration started, length of oxytocin administration, cesarean section rate, complications of delivery, birth weight, or Apgar scores. The maximal oxytocin dose in the 30-minute interval group was significantly lower. This group also had the oxytocin infusion stopped for evidence of uterine hyperstimulation and/or abnormal fetal heart rate tracing significantly less often (6.9% for the 30-minute interval versus 17.8% for the 15-minute interval; P = .0017). Overall, these results suggest that the longer interval does not increase the length of labor but decreases the incidence of uterine hyperstimulation.
在两家机构对两种不同的缩宫素引产方案进行了回顾性比较。一种方案中，剂量增加的间隔时间为15分钟；另一种方案中，该间隔时间为30分钟。所有研究患者均为初产妇，妊娠无并发症且处于自然活跃期分娩；15分钟组有92例患者，30分钟组有82例患者。在年龄、开始使用缩宫素时的宫颈扩张程度、缩宫素使用时长、剖宫产率、分娩并发症、出生体重或阿氏评分方面均未显示出差异。30分钟间隔组的最大缩宫素剂量显著更低。该组因子宫过度刺激和/或异常胎心监护而停止缩宫素输注的情况也明显更少（30分钟间隔组为6.9%，15分钟间隔组为17.8%；P = 0.0017）。总体而言，这些结果表明较长的间隔时间不会增加产程，但会降低子宫过度刺激的发生率。
