Gonser M
Department of Obstetrics and Gynecology, University Hospital Tübingen, Germany.
Arch Gynecol Obstet. 1995;256(2):63-6. doi: 10.1007/BF00634710.
Traditional protocols for oxytocin infusion regimens recommend increases of infusion rate at 15-20 min intervals. However recent clinical studies agree that prolonged intervals of 30-40 or even 60 minutes are superior to shorter dosage intervals in terms of safety and efficacy. These results are in good agreement with recent pharmacologic data on oxytocin in pregnant women, showing a half-life of about 15 minutes, and of current pharmacokinetic principles, which indicate that at least 3 half-lives of constant infusion will elapse before the corresponding clinical effect may be established. Increasing the oxytocin infusion earlier, could cause excessive uterine contractions and fetal distress.
传统的催产素输注方案建议每隔15 - 20分钟提高一次输注速率。然而，最近的临床研究一致认为，在安全性和有效性方面，30 - 40分钟甚至60分钟的较长间隔优于较短的给药间隔。这些结果与最近关于孕妇催产素的药理学数据非常吻合，该数据显示其半衰期约为15分钟，也与当前的药代动力学原理相符，这些原理表明，在建立相应的临床效果之前，至少会经过3个恒定输注半衰期。过早增加催产素输注量可能会导致子宫过度收缩和胎儿窘迫。
