Department of Ophthalmology, College of Medicine, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul, #06974, South Korea.
Graefes Arch Clin Exp Ophthalmol. 2020 Jan;258(1):39-47. doi: 10.1007/s00417-019-04475-z. Epub 2019 Nov 3.
To assess the effect of pan-retinal photocoagulation (PRP) on choroidal vascular parameters in eyes with advanced diabetic retinopathy (DR).
Forty patients (65 eyes) with severe nonproliferative DR or proliferative DR who underwent PRP were included. Changes in choroidal vascular parameters were assessed at 3, 6, and 12 months after PRP by using swept-source optical coherence tomography (OCT) and OCT angiography and were compared with baseline values.
Choroidal vascularity index (CVI) significantly decreased from 66.27% ± 1.55% at baseline to 65.85% ± 1.61%, 65.77% ± 1.29%, and 65.74% ± 1.60% at 3, 6, and 12 months after PRP, respectively. The ratio of luminal area to stromal area (L/S ratio) also significantly decreased from 1.98 ± 0.15 at baseline to 1.94 ± 0.14, 1.95 ± 0.13, and 1.93 ± 0.14 at 3, 6, and 12 months after PRP, respectively. The subfoveal choroidal thickness (SFCT) similarly showed a significant decrease from 319.50 ± 56.64 μm at baseline to 299. 07 ± 51.14 μm, 294.70 ± 58.96 μm, and 280.93 ± 53.57 μm at 3, 6, and 12 months after PRP, respectively. However, the choriocapillaris vessel density in both the fovea and parafovea showed no significant differences following PRP.
Eyes with advanced DR showed a significant reduction in CVI, L/S ratio, and SFCT over 12 months after PRP treatment.
评估全视网膜光凝（PRP）对晚期糖尿病视网膜病变（DR）患者脉络膜血管参数的影响。
纳入 40 例（65 只眼）严重非增殖性 DR 或增殖性 DR 患者，行 PRP 治疗。应用扫频源光学相干断层扫描（OCT）和 OCT 血管造影术分别于 PRP 治疗后 3、6 和 12 个月评估脉络膜血管参数的变化，并与基线值进行比较。
脉络膜血管指数（CVI）从基线时的 66.27%±1.55%分别显著下降至 PRP 治疗后 3、6 和 12 个月时的 65.85%±1.61%、65.77%±1.29%和 65.74%±1.60%。管腔面积与基质面积比（L/S 比）也从基线时的 1.98±0.15 显著下降至 PRP 治疗后 3、6 和 12 个月时的 1.94±0.14、1.95±0.13 和 1.93±0.14。脉络膜中心凹下厚度（SFCT）也从基线时的 319.50±56.64μm 显著下降至 PRP 治疗后 3、6 和 12 个月时的 299.07±51.14μm、294.70±58.96μm 和 280.93±53.57μm。然而，PRP 后，中心凹和旁中心凹的脉络膜毛细血管密度均无显著差异。
晚期 DR 患者在 PRP 治疗后 12 个月内 CVI、L/S 比和 SFCT 显著降低。
