绝经后黑人和白人女性阴道微生物组的比较。
Comparison of the Vaginal Microbiota in Postmenopausal Black and White Women.
机构信息
Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
出版信息
J Infect Dis. 2021 Dec 1;224(11):1945-1949. doi: 10.1093/infdis/jiaa780.
Abstract
BACKGROUND
We compared vaginal microbial communities in postmenopausal black and white women.
METHODS
Shotgun sequencing of vaginal swabs from postmenopausal women self-identified as black or white was compared using MiRKAT.
RESULTS
Vaginal community dominance by Lactobacillus crispatus or Lactobacillusgasseri was more common in 44 postmenopausal black women (n = 12, 27%) than among 44 matched white women (n = 2, 5%; P = .01). No individual taxa were significantly more abundant in either group.
CONCLUSIONS
We identified small overall differences in vaginal microbial communities of black and white postmenopausal women. L. crispatus dominance was more common in black women.
CLINICAL TRIALS REGISTRATION
NCT02516202 (MsFLASH05) and NCT01418209 (MsFLASH03).
摘要
背景
我们比较了绝经后黑人和白人女性的阴道微生物群落。
方法
使用 MiRKAT 比较了自我认定为黑人和白人的绝经后女性阴道拭子的鸟枪法测序结果。
结果
44 名绝经后黑人女性（n=12，27%）阴道群落以乳酸杆菌crispatus 或乳酸杆菌gasseri 为主，明显多于 44 名匹配的白人女性（n=2，5%；P=0.01）。两组中没有任何一种分类群的丰度明显更高。
结论
我们发现绝经后黑人和白人女性阴道微生物群落存在微小的总体差异。L. crispatus 优势在黑人女性中更为常见。
临床试验注册
NCT02516202（MsFLASH05）和 NCT01418209（MsFLASH03）。
相似文献
1
Comparison of the Vaginal Microbiota in Postmenopausal Black and White Women.绝经后黑人和白人女性阴道微生物组的比较。
J Infect Dis. 2021 Dec 1;224(11):1945-1949. doi: 10.1093/infdis/jiaa780.
2
Associations between the vaginal microbiome and Candida colonization in women of reproductive age.育龄妇女阴道微生物群与假丝酵母菌定植的相关性。
Am J Obstet Gynecol. 2020 May;222(5):471.e1-471.e9. doi: 10.1016/j.ajog.2019.10.008. Epub 2019 Oct 22.
3
Vaginal microbiome Lactobacillus crispatus is heritable among European American women.欧洲裔美国女性阴道微生物组中的卷曲乳杆菌具有遗传性。
Commun Biol. 2021 Aug 5;4(1):872. doi: 10.1038/s42003-021-02394-6.
4
Race, the Vaginal Microbiome, and Spontaneous Preterm Birth.种族、阴道微生物组与自发性早产。
mSystems. 2022 Jun 28;7(3):e0001722. doi: 10.1128/msystems.00017-22. Epub 2022 May 18.
5
Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation.绝经后外阴阴道不适、阴道微生物群与黏膜炎症之间的关系。
Am J Obstet Gynecol. 2021 Aug;225(2):159.e1-159.e15. doi: 10.1016/j.ajog.2021.02.034. Epub 2021 Mar 4.
6
Association between vaginal microbiota and vaginal inflammatory immune markers in postmenopausal women.绝经后女性阴道微生物群与阴道炎症免疫标志物之间的关联。
Menopause. 2024 Jul 1;31(7):575-581. doi: 10.1097/GME.0000000000002362. Epub 2024 May 7.
7
Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women.在美国两个不同种族的女性队列中复制和完善早产的阴道微生物特征。
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9966-9971. doi: 10.1073/pnas.1705899114. Epub 2017 Aug 28.
8
The vaginal bacterial communities of Japanese women resemble those of women in other racial groups.日本女性的阴道细菌群落与其他种族群体的女性相似。
FEMS Immunol Med Microbiol. 2010 Mar;58(2):169-81. doi: 10.1111/j.1574-695X.2009.00618.x. Epub 2009 Oct 3.
9
Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women.阴道毛滴虫与育龄期妇女阴道细菌群落组成的相关性。
Sex Transm Dis. 2012 Oct;39(10):807-12. doi: 10.1097/OLQ.0b013e3182631c79.
10
The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study.阴道微生物组作为体外受精（无论是否进行胞浆内单精子注射）结局的预测因素：一项前瞻性研究。
Hum Reprod. 2019 Jun 4;34(6):1042-1054. doi: 10.1093/humrep/dez065.
引用本文的文献
1
Beyond hormones: 3PM approach to vaginal microbiota dynamics in postmenopausal women.超越激素：绝经后女性阴道微生物群动态变化的下午3点研究方法
EPMA J. 2025 Apr 15;16(2):299-350. doi: 10.1007/s13167-025-00406-7. eCollection 2025 Jun.
2
Aging Is Associated With Decreased Lactobacillus and Increased Cervicovaginal Inflammation in Canadian Women.衰老与加拿大女性阴道乳酸杆菌减少及宫颈阴道炎症增加有关。
Am J Reprod Immunol. 2025 Feb;93(2):e70058. doi: 10.1111/aji.70058.
3
Vaginal Microbiome: Environmental, Biological, and Racial Influences on Gynecological Health Across the Lifespan.阴道微生物群：生命周期中环境、生物和种族对妇科健康的影响
Am J Reprod Immunol. 2024 Dec;92(6):e70026. doi: 10.1111/aji.70026.
4
The Postmenopausal Vaginal Microbiome and Genitourinary Syndrome of Menopause.绝经后阴道微生物组与绝经后泌尿生殖系统综合征。
Clin Obstet Gynecol. 2024 Mar 1;67(1):79-88. doi: 10.1097/GRF.0000000000000832. Epub 2023 Nov 20.
5
Short-Chain Fatty Acids Impair Neutrophil Antiviral Function in an Age-Dependent Manner.短链脂肪酸以年龄依赖的方式损害中性粒细胞的抗病毒功能。
Cells. 2022 Aug 13;11(16):2515. doi: 10.3390/cells11162515.
6
The association between the pre-pregnancy vaginal microbiome and time-to-pregnancy: a Chinese pregnancy-planning cohort study.孕前阴道微生物群与妊娠时间的关系：一项中国妊娠计划队列研究。
BMC Med. 2022 Aug 1;20(1):246. doi: 10.1186/s12916-022-02437-7.
7
Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation.乳杆菌属的半胱氨酸依赖性是阴道微生物组调节的一个潜在治疗靶点。
Nat Microbiol. 2022 Mar;7(3):434-450. doi: 10.1038/s41564-022-01070-7. Epub 2022 Mar 3.
本文引用的文献
1
Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.定义南非感染艾滋病毒风险较高的青少年女孩和年轻妇女的生殖健康特征。
PLoS One. 2019 Apr 4;14(4):e0213975. doi: 10.1371/journal.pone.0213975. eCollection 2019.
2
Association between obesity and bacterial vaginosis as assessed by Nugent score.Nugent 评分评估肥胖与细菌性阴道病的相关性。
Am J Obstet Gynecol. 2019 May;220(5):476.e1-476.e11. doi: 10.1016/j.ajog.2019.01.229. Epub 2019 Jan 29.
3
Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial.阴道用雌激素或阴道润滑剂与安慰剂治疗绝经后外阴阴道症状的疗效：一项随机临床试验。
JAMA Intern Med. 2018 May 1;178(5):681-690. doi: 10.1001/jamainternmed.2018.0116.
4
Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis.阴道微生物群与泌尿生殖系统更年期症状：一项横断面分析
Menopause. 2017 Oct;24(10):1160-1166. doi: 10.1097/GME.0000000000000904.
5
Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.缺乏乳酸杆菌的宫颈阴道细菌群落与南非年轻女性感染艾滋病毒的风险增加有关。
Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.
6
Prevalence and correlates of vaginal estrogenization in postmenopausal women in the United States.美国绝经后女性阴道雌激素化的患病率及其相关因素
Menopause. 2017 May;24(5):536-545. doi: 10.1097/GME.0000000000000787.
7
Reduced levels of genital tract immune biomarkers in postmenopausal women: implications for HIV acquisition.绝经后女性生殖道免疫生物标志物水平降低：对获得性HIV感染的影响。
Am J Obstet Gynecol. 2016 Sep;215(3):324.e1-324.e10. doi: 10.1016/j.ajog.2016.03.041. Epub 2016 Mar 26.
8
Association between cigarette smoking and the vaginal microbiota: a pilot study.吸烟与阴道微生物群之间的关联：一项初步研究。
BMC Infect Dis. 2014 Aug 28;14:471. doi: 10.1186/1471-2334-14-471.
9
Differences in vaginal microbiome in African American women versus women of European ancestry.非裔美国女性与欧洲裔女性阴道微生物群的差异。
Microbiology (Reading). 2014 Oct;160(Pt 10):2272-2282. doi: 10.1099/mic.0.081034-0. Epub 2014 Jul 29.
10
Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection.阴道微生物群的时间动态与人类乳头瘤病毒检测之间的相互作用。
J Infect Dis. 2014 Dec 1;210(11):1723-33. doi: 10.1093/infdis/jiu330. Epub 2014 Jun 18.
Zotero 插件