Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.
Int J Oncol. 2021 Jan;58(1):9-19. doi: 10.3892/ijo.2020.5152. Epub 2020 Nov 25.
Mammalian target of rapamycin (mTOR) serves an important role in regulating various biological processes, including cell proliferation, metabolism, apoptosis and autophagy. Among these processes, energy metabolism is the dominant process. The metabolism of not only amino acids, fatty acids and lipids, but also that of nucleotides and glucose has been indicated to be regulated by mTOR. Aerobic glycolysis, which is a specific form of glucose metabolism, is prevalent in carcinomas, and it has been considered to be a potential target for cancer therapy. In reviewing the complexity of the mTOR pathway, it is important to elucidate the central role and detailed pathway via which mTOR regulates glycolysis. In the present study, the complex mechanisms via which mTOR regulates aerobic glycolysis were comprehensively reviewed to highlight the potential of drug development via targeting the molecules associated with mTOR and glycolysis and to further provide strategies for the clinical treatment of cancer.
哺乳动物雷帕霉素靶蛋白（mTOR）在调节各种生物过程中起着重要作用，包括细胞增殖、代谢、凋亡和自噬。在这些过程中，能量代谢是占主导地位的过程。不仅氨基酸、脂肪酸和脂质的代谢，而且核苷酸和葡萄糖的代谢都被表明受到 mTOR 的调节。有氧糖酵解是葡萄糖代谢的一种特殊形式，在癌中很常见，被认为是癌症治疗的潜在靶点。在回顾 mTOR 途径的复杂性时，阐明 mTOR 调节糖酵解的核心作用和详细途径非常重要。在本研究中，综合综述了 mTOR 调节有氧糖酵解的复杂机制，以强调通过靶向与 mTOR 和糖酵解相关的分子开发药物的潜力，并为癌症的临床治疗提供策略。
