Department of Surgery, Ankara City Hospital, Ankara, Turkey.
Department of Pulmonary Diseases, Ankara Abdurrahman Yurtaslan Oncology Hospital, Ankara, Turkey.
Int J Clin Pract. 2021 May;75(5):e13970. doi: 10.1111/ijcp.13970. Epub 2021 Jan 6.
Coronavirus-19 is a rapidly progressing disease that can result in mortality. We aimed to evaluate the efficacy of the delta neutrophil index in predicting mortality in intensive care patients diagnosed with Coronavirus-19.
Patients with a positive polymerase chain reaction test and/or computed tomography findings compatible with the disease were included in the study. The demographic characteristics of the patients, polymerase chain reaction test results, chest computed tomography findings, blood parameters at the time of presentation, 30-day mortality, and the number of days in the intensive care unit were assessed.
Of the 388 patients receiving intensive care, 220 (56.7%) were men and 168 (43.3%) were women. The mean age was 70 ± 15 years. The evaluation of mortality, 264 (68%) of the patients survived and 124 (32%) died. The delta neutrophil index, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein values were statistically significantly higher and the lymphocyte value was significantly lower in the mortality group (P = .003, .034, .000, .002, .000 and .024, respectively). In the receiver operating characteristic curve analysis, the area under the curve values of the delta neutrophil index, lymphocyte, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein levels in predicting mortality were 0.718, 0.416, 0.628, 0.585, 0.701 and 0.684, respectively.
We consider that the delta neutrophil index can be used as an effective prognostic parameter to show intensive care mortality in patients with Coronavirus-19.
新冠病毒是一种快速发展的疾病，可导致死亡。我们旨在评估中性粒细胞 delta 指数在预测新冠肺炎重症监护患者死亡率方面的效果。
本研究纳入了聚合酶链反应检测阳性和/或符合疾病的计算机断层扫描结果的患者。评估了患者的人口统计学特征、聚合酶链反应检测结果、胸部计算机断层扫描结果、就诊时的血液参数、30 天死亡率和重症监护病房的天数。
在接受重症监护的 388 名患者中，220 名（56.7%）为男性，168 名（43.3%）为女性。平均年龄为 70±15 岁。评估死亡率时，264 名（68%）患者存活，124 名（32%）死亡。死亡率组的中性粒细胞 delta 指数、中性粒细胞与淋巴细胞比值、乳酸、白细胞介素-6 和 C 反应蛋白值显著较高，淋巴细胞值显著较低（P=.003、.034、.000、.002、.000 和.024）。在受试者工作特征曲线分析中，中性粒细胞 delta 指数、淋巴细胞、中性粒细胞与淋巴细胞比值、乳酸、白细胞介素-6 和 C 反应蛋白水平预测死亡率的曲线下面积值分别为 0.718、0.416、0.628、0.585、0.701 和 0.684。
我们认为，中性粒细胞 delta 指数可作为一种有效的预后参数，用于显示新冠肺炎重症监护患者的死亡率。
