SeyedAlinaghi SeyedAhmad, Karimi Amirali, Mirzapour Pegah, Afroughi Fatemeh, Noroozi Alireza, Arjmand Ghazal, Abshenas Shayan, Pashaei Zahra, Tantuoyir Marcarious M, Dadras Omid, Qaderi Kowsar, Saeidi Solmaz, Dehghani Soheil, Shabanzadeh Pirsaraie Ayda, Mehraeen Esmaeil, Afsahi Amir Masoud
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors Tehran University of Medical Sciences Tehran Iran.
School of Medicine Tehran University of Medical Sciences Tehran Iran.
Health Sci Rep. 2022 Oct 7;5(6):e868. doi: 10.1002/hsr2.868. eCollection 2022 Nov.
C-reactive protein (CRP) and cytokines levels could alter in patients with coronavirus disease (COVID-19) due to the inflammatory response caused by the virus. This analysis aimed to assess the relationship between the CRP levels and the levels of various cytokines in COVID-19 patients.
We searched the databases of PubMed, Cochrane, and Web of Science for relevant articles on May 29th, 2021. Applying the inclusion/exclusion criteria, the retrieved records underwent two-phase screenings; first, a title/abstract screening process, and then, a full-text screening to find the eligible studies. Data for study variables were extracted, including the CRP levels and the levels of all reported cytokines. A strong and significant relationship between Interleukins and CRP was defined as: ≤ 0.05, 0.7 ≤ ≤ 1.
In this study, 103 studies were included for systematic review and correlation analysis. The aggregate mean and SD of study variables were calculated and reported. The correlation between Interleukins and CRP was measured using correlation coefficient (). It appeared that interleukin (IL)-10 has a moderate and significant relationship with CRP ( ≤ 0.05, = 0.472). IL-10 predicted almost 10% of CRP changes.
This correlation analysis suggests IL-10 is moderately correlated with CRP levels in patients with COVID-19 infection. A better understanding of the pro-inflammatory markers could contribute to the implementation of therapeutic and preventive approaches. More prospective studies are suggested to explore the relationship between CRP and cytokines as potential markers for the early identification of COVID-19 progression and severity.
由于冠状病毒病（COVID-19）病毒引发的炎症反应，患者体内的C反应蛋白（CRP）和细胞因子水平可能会发生变化。本分析旨在评估COVID-19患者CRP水平与各种细胞因子水平之间的关系。
我们于2021年5月29日在PubMed、Cochrane和Web of Science数据库中搜索相关文章。应用纳入/排除标准，对检索到的记录进行两阶段筛选；首先是标题/摘要筛选过程，然后是全文筛选以找到符合条件的研究。提取研究变量的数据，包括CRP水平和所有报告的细胞因子水平。白细胞介素与CRP之间的强显著关系定义为：≤0.05，0.7≤≤1。
本研究纳入103项研究进行系统评价和相关性分析。计算并报告了研究变量的总体均值和标准差。使用相关系数（）测量白细胞介素与CRP之间的相关性。结果显示，白细胞介素（IL）-10与CRP存在中度显著关系（≤0.05，=0.472）。IL-10可预测近10%的CRP变化。
该相关性分析表明，IL-10与COVID-19感染患者的CRP水平呈中度相关。更好地了解促炎标志物有助于实施治疗和预防方法。建议开展更多前瞻性研究，以探索CRP与细胞因子之间的关系，作为早期识别COVID-19进展和严重程度的潜在标志物。
