Hellenic Centre for Marine Research (HCMR), Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Anavyssos, Attika, Greece.
Hellenic Centre for Marine Research (HCMR), Institute of Marine Biology, Biotechnology and Aquaculture (IMBBC), Former American Base of Gournes, Heraklion, Crete, Greece.
Vet Med Sci. 2021 May;7(3):987-997. doi: 10.1002/vms3.415. Epub 2020 Dec 23.
The pharmacokinetic properties and residue elimination of florfenicol (FLO) and its amine were investigated in European seabass Dicentrarchus labrax at 24°C. The trial mainly included analysis of FLO in plasma after a single dose dietary administration of 10 mg/kg and in muscle plus skin following a multiple dosing (10 mg kg day for 7 days) to estimate pharmacokinetics and residue depletion, respectively. The maximum plasma concentration of FLO was measured to be 1.64 μg/ml, 4 hr post administration. The elimination half-life (t ) and the area under the concentration-time curve extrapolated to infinity (AUC ) were calculated to be 13.0 hr and 34.7 μg h ml , respectively. Withdrawal times of FLO and its amine were calculated to be 46.3 degree-days, indicating a fast removal from the edible tissues of treated European seabass. Overall, FLO can be considered as a potentially efficient antibacterial agent for farmed European seabass provided that additional efforts will be devoted towards its in vitro and clinical efficacy.
在 24°C 下，研究了氟苯尼考（FLO）及其胺在欧洲鲈鱼（Dicentrarchus labrax）中的药代动力学特性和残留消除。该试验主要包括分析欧洲鲈鱼单次经口摄入 10mg/kg 剂量和多次（连续 7 天每天 10mg/kg）给药后肌肉加皮肤中的 FLO，以分别估计药代动力学和残留消除。给药后 4 小时，最大 FLO 血浆浓度为 1.64μg/ml。半衰期（t ）和 extrapolated 至无穷大的浓度-时间曲线下面积（AUC ）分别计算为 13.0 小时和 34.7μg·h·ml 。FLO 和其胺的停药时间计算为 46.3 度日，表明从处理过的欧洲鲈鱼可食用组织中快速去除。总的来说，FLO 可以被认为是一种对养殖欧洲鲈鱼有潜在高效的抗菌剂，前提是将更多的努力投入到其体外和临床疗效的研究中。
