[支架降解与血管重塑耦合效应的生物力学建模研究综述]
[Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].
作者信息
Zhang Hanbing, Zhang Yu, Chen Shiliang, Cui Xinyang, Peng Kun, Qiao Aike
机构信息
Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Dec 25;37(6):956-966. doi: 10.7507/1001-5515.202008007.
The dynamic coupling of stent degradation and vessel remodeling can influence not only the structural morphology and material property of stent and vessel, but also the development of in-stent restenosis. The research achievements of biomechanical modelling and analysis of stent degradation and vessel remodeling were reviewed; several noteworthy research perspectives were addressed, a stent-vessel coupling model was developed based on stent damage function and vessel growth function, and then concepts of matching ratio and risk factor were established so as to evaluate the treatment effect of stent intervention, which may lay the scientific foundation for the structure design, mechanical analysis and clinical application of biodegradable stent.
支架降解与血管重塑的动态耦合不仅会影响支架和血管的结构形态与材料性能，还会影响支架内再狭窄的发展。综述了支架降解与血管重塑的生物力学建模及分析研究成果；探讨了几个值得关注的研究方向，基于支架损伤函数和血管生长函数建立了支架-血管耦合模型，进而确立了匹配比和危险因素的概念以评估支架干预的治疗效果，这可能为可降解支架的结构设计、力学分析及临床应用奠定科学基础。
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