Latorre Marcos, Humphrey Jay D
Department of Biomedical Engineering Yale University, New Haven, CT 06520, USA.
Vascular Biology and Therapeutics Program Yale School of Medicine, New Haven, CT 06520, USA.
J Mech Phys Solids. 2019 Apr;125:298-325. doi: 10.1016/j.jmps.2018.12.013. Epub 2018 Dec 21.
Like all other materials, biological soft tissues are subject to general laws of physics, including those governing mechanical equilibrium and stability. In addition, however, these tissues are able to respond actively to changes in their mechanical and chemical environment. There is, therefore, a pressing need to understand such processes theoretically. In this paper, we present a new rate-based constrained mixture formulation suitable for studying mechanobiological equilibrium and stability of soft tissues exposed to transient or sustained changes in material composition or applied loading. These concepts are illustrated for canonical problems in arterial mechanics, which distinguish possible stable versus unstable mechanobiological responses. Such analyses promise to yield insight into biological processes that govern both health and disease progression.
与所有其他材料一样，生物软组织也遵循一般的物理定律，包括那些支配机械平衡和稳定性的定律。然而，除此之外，这些组织能够对其机械和化学环境的变化做出积极响应。因此，迫切需要从理论上理解这些过程。在本文中，我们提出了一种新的基于速率的约束混合物公式，适用于研究暴露于材料组成或施加载荷的瞬态或持续变化的软组织的力学生物学平衡和稳定性。这些概念通过动脉力学中的典型问题进行了说明，这些问题区分了可能的稳定与不稳定的力学生物学响应。此类分析有望深入了解控制健康和疾病进展的生物学过程。
