Université de Brest, Université d'Angers, GEIHP, Brest, France.
Laboratory of Parasitology and Mycology, Brest University Hospital, Brest, France.
Med Mycol. 2021 May 4;59(5):510-513. doi: 10.1093/mmy/myaa107.
Pulmonary specimen pairs from five patients who presented with pulmonary colonization and later developed Pneumocystis Pneumonia (PcP) were retrospectively examined for P. jirovecii genotyping. A match of genotypes in pulmonary specimen pairs of three patients was observed, whereas a partial match and a mismatch were observed in the fourth and fifth patients, respectively. The genotyping results suggest that the colonization state can differ from PcP but can also represent the incubation period of PcP. Clinicians should not systematically rule out the treatment of putative colonized patients and should at least discuss the initiation of prophylaxis on a case-by-case basis.
回顾性分析了 5 例出现肺部定植、随后发生卡氏肺孢子菌肺炎（PcP）的患者的肺部标本，以进行肺孢子菌基因型检测。在 3 例患者的肺部标本配对中观察到基因型匹配，而在第 4 例和第 5 例患者中分别观察到部分匹配和不匹配。基因分型结果表明，定植状态可能与 PcP 不同，但也可能代表 PcP 的潜伏期。临床医生不应该系统地排除疑似定植患者的治疗，至少应该根据具体情况讨论预防用药的启动。
