Hospital Universitário do Oeste do Paraná, Cascavel, PR, Brazil.
Universidade Federal de São Paulo, Laboratório Especial de Micologia, São Paulo, SP, Brazil.
Braz J Infect Dis. 2021 Jan-Feb;25(1):101041. doi: 10.1016/j.bjid.2020.11.006. Epub 2020 Dec 25.
Candida spp. has been reported as one of the common agents of nosocomial bloodstream infections and is associated with a high mortality. Therefore, this study evaluated the clinical findings, local epidemiology, and microbiological aspects of candidemia in eight tertiary medical centers in the state of Parana, South of Brazil.
In this study, we reported 100 episodes of candidemia in patients admitted to eight different hospitals in five cities of the state of Parana, Brazil, using data collected locally (2016 and 2017) and tabulated online.
The incidence was found to be 2.7 / 1000 patients / day and 1.2 / 1000 admissions. C. albicans was responsible for 49% of all candidemia episodes. Cancer and surgery were the two most common underlying conditions associated with candidemia. The mortality rate within 30 days was 48%, and removal of the central venous catheter (p = 0.029) as well as empirical or prophylactic exposure to antifungals were both related to improved survival (p = 0.033).
This study highlights the high burden and mortality rates of candidemia in hospitals from Parana as well as the need to enhance antifungal stewardship program in the enrolled medical centers.
念珠菌属已被报道为医院获得性血流感染的常见病原体之一，与高死亡率相关。因此，本研究评估了巴西南部巴拉那州 8 家三级医疗中心的念珠菌血症的临床发现、局部流行病学和微生物学特征。
本研究报告了巴西巴拉那州 5 个城市的 8 家不同医院 100 例住院患者的念珠菌血症病例，使用本地（2016 年和 2017 年）收集和在线表格的数据。
发病率为 2.7/1000 患者/天和 1.2/1000 人次。所有念珠菌血症病例中，白念珠菌占 49%。癌症和手术是与念珠菌血症最相关的两种最常见的基础疾病。30 天内死亡率为 48%，并且移除中心静脉导管（p=0.029）以及经验性或预防性使用抗真菌药物与生存改善相关（p=0.033）。
本研究强调了巴拉那州医院念珠菌血症的高负担和高死亡率，以及需要加强所涉及医疗中心的抗真菌药物管理计划。
