Salonen J T, Slater J S, Tuomilehto J, Rauramaa R
Department of Community Health, University of Kuopio, Finland.
Am J Epidemiol. 1988 Jan;127(1):87-94. doi: 10.1093/oxfordjournals.aje.a114794.
The relation of leisure time and occupational physical activity to the risk of death from ischemic heart disease was investigated in a cohort of 15,088 persons aged 30-59 years who had no history of cardiovascular disease or other condition which hindered physical activity. Two population samples were randomly chosen from eastern Finland. During a six-year follow-up, persons who were sedentary in leisure time (relative risk = 1.3, 95% confidence interval (CI) = 1.1-1.6) or at work (relative risk = 1.3, 95% CI = 1.1-1.6) had an excess risk of ischemic heart disease death when adjusted for age, health status, family history, and body mass index in multivariate logistic models. Adjustment for years of education, social network participation, cigarette consumption, serum cholesterol level, and blood pressure level weakened the residual association of low leisure time physical activity with the risk of ischemic heart disease death (relative risk = 1.2, 95% CI = 1.0-1.5), whereas the association for low occupational physical activity remained unchanged. The lack of leisure time physical activity and a sedentary occupation are associated with an increased risk of ischemic heart disease death, and the excess risk due to lack of leisure time physical activity is, in part, accounted for by other ischemic heart disease risk factors.
在一个由15088名年龄在30至59岁之间、无心血管疾病或其他妨碍身体活动疾病史的人群队列中，研究了休闲时间和职业体力活动与缺血性心脏病死亡风险之间的关系。从芬兰东部随机选取了两个人口样本。在为期六年的随访中，在多因素逻辑模型中对年龄、健康状况、家族史和体重指数进行调整后，休闲时间久坐不动的人（相对风险=1.3，95%置信区间（CI）=1.1 - 1.6）或工作时久坐不动的人（相对风险=1.3，95%CI = 1.1 - 1.6）患缺血性心脏病死亡的风险更高。对受教育年限、社交网络参与度、吸烟量、血清胆固醇水平和血压水平进行调整后，低休闲时间体力活动与缺血性心脏病死亡风险之间的残余关联减弱（相对风险=1.2，95%CI = 1.0 - 1.5），而低职业体力活动的关联保持不变。休闲时间缺乏体力活动和久坐的职业与缺血性心脏病死亡风险增加相关，并且休闲时间缺乏体力活动导致的额外风险部分由其他缺血性心脏病风险因素所致。
