代谢组学揭示了海洋无脊椎动物食物链中的少量 Tambjamines。
Metabolomics Reveals Minor Tambjamines in a Marine Invertebrate Food Chain.
机构信息
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP, São Carlos, SP 13560-970, Brazil.
Department of Chemistry, University of California, Berkeley, California 94720, United States.
出版信息
J Nat Prod. 2021 Mar 26;84(3):790-796. doi: 10.1021/acs.jnatprod.0c01043. Epub 2020 Dec 29.
Abstract
Metabolomics analysis detected tambjamine alkaloids in aqueous and EtOAc extracts of the marine invertebrates , , , and . Among several tambjamines, the new amino acid derivatives tambjamines M-O (-) were identified by Marfey's advanced analysis, UPLC-MS/MS analyses, and total synthesis. The tambjamine diversity increased from the bryozoan to its nudibranch predators and and attained a higher diversity in , the nudibranch that preys upon and . The total tambjamine content also increases among the trophic levels, probably due to biomagnification. Tambjamines A (), C (), and D () are the major metabolites in the tissues of , , , and and are likely the main chemical defenses of these marine invertebrates.
摘要
代谢组学分析检测到海洋无脊椎动物、、、和中含有 Tambjamine 生物碱。在几种 Tambjamine 中，通过 Marfey 的高级分析、UPLC-MS/MS 分析和全合成鉴定了新的氨基酸衍生物 Tambjamine M-O(-)。Tambjamine 的多样性从苔藓虫增加到其裸鳃类捕食者和，并在以捕食和为食的裸鳃类中达到更高的多样性。总 Tambjamine 含量也在营养级之间增加，可能是由于生物放大作用。Tambjamines A()、C()和 D()是、、和组织中的主要代谢物，可能是这些海洋无脊椎动物的主要化学防御物质。
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