Servillera Máximo, Peña Mercedes, Cabeza Laura, Pula Héctor J, Prados Jose, Melguizo Consolación
Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.
Instituto de Investigación Biosanitaria de Granada, ibs.GRANADA, 18012 Granada, Spain.
Mar Drugs. 2025 Aug 3;23(8):319. doi: 10.3390/md23080319.
Nudibranchs have garnered increasing interest in biomedical research due to their complex chemical defense mechanisms, many of which are derived from their diet, including sponges, cnidarians, tunicates, and algae. Their remarkable ability to sequester dietary toxins and synthesize secondary metabolites positions them as a promising source of biologically active compounds with potential therapeutic applications, particularly in oncology. This study aimed to review and summarize the available literature on the bioactive potential of nudibranch-derived compounds, focusing mainly on their antitumor properties. Although research in this area is still limited, recent studies have identified alkaloids and terpenoids isolated from species such as , , , and members of the genus . These compounds exhibit notable cytotoxic activity against human cancer cell lines, including those from colon (HCT-116, HT-29, SW-480), lung (A549), and breast (MCF7) cancer. These findings suggest that compounds derived from nudibranchs could serve as scaffolds for the development of more effective and selective anticancer therapies. In conclusion, nudibranchs represent a valuable yet underexplored resource for antitumor drug discovery, with significant potential to contribute to the development of novel cancer treatments.
由于裸鳃亚目动物复杂的化学防御机制，它们在生物医学研究中越来越受到关注，其中许多机制源自它们的食物，包括海绵、刺胞动物、被囊动物和藻类。它们摄取膳食毒素并合成次生代谢产物的卓越能力，使它们成为具有潜在治疗应用的生物活性化合物的一个有前景的来源，尤其是在肿瘤学领域。本研究旨在回顾和总结关于裸鳃亚目动物衍生化合物生物活性潜力的现有文献，主要关注它们的抗肿瘤特性。尽管该领域的研究仍然有限，但最近的研究已经鉴定出从诸如 、 、 以及 属的成员等物种中分离出的生物碱和萜类化合物。这些化合物对人类癌细胞系表现出显著的细胞毒性活性，包括来自结肠（HCT - 116、HT - 29、SW - 480）、肺（A549）和乳腺（MCF7）癌的细胞系。这些发现表明，源自裸鳃亚目动物的化合物可以作为开发更有效和更具选择性抗癌疗法的支架。总之，裸鳃亚目动物是抗肿瘤药物发现的一种有价值但尚未充分探索的资源，对新型癌症治疗的开发具有重大贡献潜力。
