• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

冠状病毒 SARS-CoV-2 的免疫系统观点。

The immune system view of the coronavirus SARS-CoV-2.

机构信息

Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Rome, Italy.

Armenise-Harvard Immune Regulation Unit, Italian Institute for Genomic Medicine, FPO IRCCS Candiolo, Turin, Italy.

出版信息

Biol Direct. 2020 Dec 29;15(1):30. doi: 10.1186/s13062-020-00283-2.

DOI:10.1186/s13062-020-00283-2
PMID:33371901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7769684/
Abstract

Knowing the "point of view" of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disease (COVID)-19. In this review, we will discuss the general host/pathogen interactions dictating protective immune response or immunopathology, addressing the role of immunity or immunopathology in influencing the clinical infection outcome, and debate the potential immunoprophylactic and immunotherapy strategies required to fight the virus infection.

摘要

了解免疫系统的“观点”对于理解大流行的特征至关重要，例如由严重急性呼吸系统综合征冠状病毒（SARS-CoV-2）引起的大流行，该病毒是导致冠状病毒病（COVID-19）的病原体。在这篇综述中，我们将讨论决定保护性免疫反应或免疫病理的一般宿主/病原体相互作用，探讨免疫或免疫病理在影响临床感染结局中的作用，并辩论对抗病毒感染所需的潜在免疫预防和免疫治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69dc/7771084/60b0a2e2400f/13062_2020_283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69dc/7771084/f30241a9fa10/13062_2020_283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69dc/7771084/60b0a2e2400f/13062_2020_283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69dc/7771084/f30241a9fa10/13062_2020_283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69dc/7771084/60b0a2e2400f/13062_2020_283_Fig2_HTML.jpg

相似文献

1
The immune system view of the coronavirus SARS-CoV-2.冠状病毒 SARS-CoV-2 的免疫系统观点。
Biol Direct. 2020 Dec 29;15(1):30. doi: 10.1186/s13062-020-00283-2.
2
The immune response to SARS-CoV-2 and COVID-19 immunopathology - Current perspectives.SARS-CoV-2 与 COVID-19 免疫病理的免疫反应——当前观点。
Pulmonology. 2021 Sep-Oct;27(5):423-437. doi: 10.1016/j.pulmoe.2021.03.008. Epub 2021 Apr 9.
3
Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2.严重急性呼吸综合征冠状病毒 2 型对 I 型干扰素的拮抗作用。
J Interferon Cytokine Res. 2020 Dec;40(12):543-548. doi: 10.1089/jir.2020.0214.
4
Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic.COVID-19 的免疫反应和潜在疫苗：从 SARS 和 MERS 疫情中吸取的教训。
Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9. doi: 10.12932/AP-200220-0772.
5
Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV.SARS-CoV-2 的先天免疫逃避：与 SARS-CoV 的比较。
Rev Med Virol. 2020 Nov;30(6):1-9. doi: 10.1002/rmv.2135. Epub 2020 Jul 30.
6
A review of monoclonal antibodies in COVID-19: Role in immunotherapy, vaccine development and viral detection.COVID-19 中单抗的研究进展：在免疫治疗、疫苗开发和病毒检测中的作用。
Hum Antibodies. 2021;29(3):179-191. doi: 10.3233/HAB-200441.
7
SARS-CoV-2-mediated immune system activation and potential application in immunotherapy.SARS-CoV-2 介导的免疫系统激活及其在免疫治疗中的潜在应用。
Med Res Rev. 2021 Mar;41(2):1167-1194. doi: 10.1002/med.21756. Epub 2020 Nov 13.
8
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses.RIG-I 样受体介导的严重急性呼吸综合征冠状病毒 2 病毒基因组 RNA 的识别及病毒逃避宿主固有免疫反应。
Front Immunol. 2021 Jun 25;12:700926. doi: 10.3389/fimmu.2021.700926. eCollection 2021.
9
Harnessing preexisting influenza virus-specific immunity increases antibody responses against SARS-CoV-2.利用预先存在的流感病毒特异性免疫力可增强针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体反应。
J Virol. 2024 Feb 20;98(2):e0157123. doi: 10.1128/jvi.01571-23. Epub 2024 Jan 11.
10
Molecular Perspectives of SARS-CoV-2: Pathology, Immune Evasion, and Therapeutic Interventions.SARS-CoV-2 的分子视角：病理学、免疫逃逸和治疗干预。
Mol Cells. 2021 Jun 30;44(6):408-421. doi: 10.14348/molcells.2021.0026.

引用本文的文献

1
Exploring the Interplay between COVID-19 and Gut Health: The Potential Role of Prebiotics and Probiotics in Immune Support.探索 COVID-19 与肠道健康的相互作用：益生元和益生菌在免疫支持中的潜在作用。
Viruses. 2024 Feb 27;16(3):370. doi: 10.3390/v16030370.
2
Analysis of Epidemiological Factors and SNP rs3804100 of for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil.分析在巴西贝伦-帕拉工作的专业人员第一波大流行期间 COVID-19 的流行病学因素和 SNP rs3804100。
Genes (Basel). 2023 Oct 5;14(10):1907. doi: 10.3390/genes14101907.
3
Impact of the New Coronavirus Infection on the Immune System of Children and Adolescents in the Region of the Russian Federation.

本文引用的文献

1
The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications.死亡结构域蛋白在新冠病毒感染后宿主反应中的作用：程序性细胞死亡的调控及转化应用
Cell Death Discov. 2020 Oct 10;6(1):101. doi: 10.1038/s41420-020-00331-w. eCollection 2020.
2
Benchmarking evolutionary tinkering underlying human-viral molecular mimicry shows multiple host pulmonary-arterial peptides mimicked by SARS-CoV-2.对人类与病毒分子模拟背后的进化修补进行基准测试表明，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）模拟了多种宿主肺动脉肽。
Cell Death Discov. 2020 Oct 2;6(1):96. doi: 10.1038/s41420-020-00321-y. eCollection 2020.
3
新型冠状病毒感染对俄罗斯联邦地区儿童和青少年免疫系统的影响。
Int J Environ Res Public Health. 2022 Oct 21;19(20):13669. doi: 10.3390/ijerph192013669.
4
Autoimmune and immunoserological markers of COVID-19 pneumonia: Can they help in the assessment of disease severity.新型冠状病毒肺炎的自身免疫和免疫血清学标志物：它们能否有助于评估疾病严重程度？
Front Med (Lausanne). 2022 Aug 29;9:934270. doi: 10.3389/fmed.2022.934270. eCollection 2022.
5
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.高度多重免疫组库测序将多种淋巴细胞类别与COVID-19的反应严重程度联系起来。
EClinicalMedicine. 2022 Jun;48:101438. doi: 10.1016/j.eclinm.2022.101438. Epub 2022 May 14.
6
Cancer treatment in the time of COVID-19 pandemics: A new concern.
Cancer. 2022 Aug 1;128(15):2991. doi: 10.1002/cncr.34249. Epub 2022 May 2.
7
Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious Responses.新冠病毒感染中的抗病毒免疫：从保护性反应到有害反应
Microorganisms. 2021 Dec 13;9(12):2578. doi: 10.3390/microorganisms9122578.
8
Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection.由 SARS-CoV-2 感染诱导的合胞体中的微核生成、DNA 损伤反应的激活和 cGAS-STING 信号转导。
Biol Direct. 2021 Oct 21;16(1):20. doi: 10.1186/s13062-021-00305-7.
9
Redressing the interactions between stem cells and immune system in tissue regeneration.在组织再生中纠正干细胞与免疫系统之间的相互作用。
Biol Direct. 2021 Oct 20;16(1):18. doi: 10.1186/s13062-021-00306-6.
10
Mutational Landscape and Interaction of SARS-CoV-2 with Host Cellular Components.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的突变图谱及其与宿主细胞成分的相互作用
Microorganisms. 2021 Aug 24;9(9):1794. doi: 10.3390/microorganisms9091794.
Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19).
骨髓来源的抑制性细胞在重症冠状病毒病（COVID-19）患者中的扩增。
Cell Death Differ. 2020 Nov;27(11):3196-3207. doi: 10.1038/s41418-020-0572-6. Epub 2020 Jun 8.
4
Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: Targeting a potential IL-1β/neutrophil extracellular traps feedback loop.针对 SARS-CoV-2 诱导的急性肺损伤的新型治疗靶点：靶向潜在的 IL-1β/中性粒细胞胞外诱捕网反馈环。
Med Hypotheses. 2020 Oct;143:109906. doi: 10.1016/j.mehy.2020.109906. Epub 2020 May 30.
5
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.羟氯喹作为 COVID-19 暴露后预防的随机试验。
N Engl J Med. 2020 Aug 6;383(6):517-525. doi: 10.1056/NEJMoa2016638. Epub 2020 Jun 3.
6
Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent.严重 COVID-19 中免疫细胞细胞毒性受损依赖于白细胞介素 6。
J Clin Invest. 2020 Sep 1;130(9):4694-4703. doi: 10.1172/JCI138554.
7
Charting the Roadmap of T Cell Exhaustion.绘制 T 细胞耗竭的路线图。
Immunity. 2020 May 19;52(5):724-726. doi: 10.1016/j.immuni.2020.04.019.
8
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.人类单克隆 SARS-CoV 抗体对 SARS-CoV-2 的交叉中和作用。
Nature. 2020 Jul;583(7815):290-295. doi: 10.1038/s41586-020-2349-y. Epub 2020 May 18.
9
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.宿主对 SARS-CoV-2 的失衡反应导致 COVID-19 的发生。
Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
10
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.SARS-CoV-2 受体 ACE2 是人类气道上皮细胞中的一种干扰素刺激基因，可在组织中的特定细胞亚群中检测到。
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27.