Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Rome, Italy.
Armenise-Harvard Immune Regulation Unit, Italian Institute for Genomic Medicine, FPO IRCCS Candiolo, Turin, Italy.
Biol Direct. 2020 Dec 29;15(1):30. doi: 10.1186/s13062-020-00283-2.
Knowing the "point of view" of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsible for the Coronavirus Disease (COVID)-19. In this review, we will discuss the general host/pathogen interactions dictating protective immune response or immunopathology, addressing the role of immunity or immunopathology in influencing the clinical infection outcome, and debate the potential immunoprophylactic and immunotherapy strategies required to fight the virus infection.
了解免疫系统的“观点”对于理解大流行的特征至关重要，例如由严重急性呼吸系统综合征冠状病毒（SARS-CoV-2）引起的大流行，该病毒是导致冠状病毒病（COVID-19）的病原体。在这篇综述中，我们将讨论决定保护性免疫反应或免疫病理的一般宿主/病原体相互作用，探讨免疫或免疫病理在影响临床感染结局中的作用，并辩论对抗病毒感染所需的潜在免疫预防和免疫治疗策略。
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