Kerstetter J R, Brubaker R F, Wilson S E, Kullerstrand L J
Mayo Medical School, Rochester, Minnesota.
Am J Ophthalmol. 1988 Jan 15;105(1):30-4. doi: 10.1016/0002-9394(88)90117-1.
Using fluorophotometry, we performed a randomized, dose-response study of the effects of a prostaglandin derivative on aqueous humor flow. Prostaglandin F2 alpha 1-isopropylester, 0.224 micrograms, 0.448 micrograms, and 1.120 micrograms, in saline with polysorbate 80 was instilled into one eye of 20 subjects in three separate dose studies. Polysorbate 80 in saline was instilled in the fellow eye as a control. The drug had no measurable effect on aqueous humor flow or corneal endothelial permeability. Intraocular pressure measured eight hours after administration of the highest dose, 1.120 micrograms, was 20% lower in the treated eye as compared to the fellow eye (P less than .001).
我们使用荧光光度法进行了一项随机剂量反应研究，以探讨一种前列腺素衍生物对房水流出的影响。在三项单独的剂量研究中，将0.224微克、0.448微克和1.120微克的前列腺素F2α 1-异丙酯溶于含有聚山梨酯80的盐水中，滴入20名受试者的一只眼睛。另一只眼睛滴入含有聚山梨酯80的盐水作为对照。该药物对房水流出或角膜内皮通透性没有可测量的影响。在给予最高剂量1.120微克八小时后测量眼压，治疗眼的眼压比另一只眼低20%（P小于0.001）。
