Santo Augusto Hasiak
Faculdade de Saúde Pública da Universidade de São Paulo (FSP USP), São Paulo, SP, Brazil (retired).
Hematol Transfus Cell Ther. 2022 Apr-Jun;44(2):177-185. doi: 10.1016/j.htct.2020.09.154. Epub 2020 Dec 5.
There is a demand to update national mortality trends data related to sickle cell disease (SCD) in Brazil. This study describes causes of death and mortality issues related to SCD using the multiple-cause-of-death methodology.
The annual SCD mortality data was extracted from the public databases of the Mortality Information System by researching deaths in rubric D57 "sickle-cell disorders" of the International Classification of Diseases, Tenth Revision and processed by the Multiple Cause Tabulator.
From 2000 to 2018 in Brazil, a total of 9817 deaths related to SCD occurred during the 19-year period, as the underlying cause in 6924 (70.5%) and as the associated cause of death in 2893 (29.5%). The mean and median ages at death during the entire period were significantly lower for males, 29.4 (±19.6) and 27.5 (15.5-41.5), respectively, than for females, 33.3 (±20.3) and 31.0 (19.5-46.5), respectively. The leading SCD overall associated causes of death were septicemias (32.1%), followed by pneumonias (19.4%) and respiratory failure (18.2%). On certificates with SCD as an associated cause, the underlying causes of death were circulatory system diseases (8.7%), followed, in males, by digestive system and infectious diseases and respiratory system failures, while in females, maternal deaths, included in the chapter on pregnancy, childbirth and the puerperium, accounting for 4.6% of female deaths, were succeeded by digestive system and infectious diseases.
This study revised mortality data on death rate trends, underlying and associated causes of death, age at death and regional distribution of death in Brazil.
巴西需要更新与镰状细胞病（SCD）相关的全国死亡率趋势数据。本研究采用多死因方法描述了与SCD相关的死亡原因和死亡率问题。
通过在国际疾病分类第十版的D57“镰状细胞疾病”类别中搜索死亡信息，从死亡率信息系统的公共数据库中提取年度SCD死亡率数据，并由多死因制表器进行处理。
2000年至2018年期间，巴西共有9817例与SCD相关的死亡，其中6924例（70.5%）为根本死因，2893例（29.5%）为相关死因。在整个时期，男性的平均死亡年龄和中位死亡年龄分别为29.4岁（±19.6）和27.5岁（15.5 - 41.5），显著低于女性，女性分别为33.3岁（±20.3）和31.0岁（19.5 - 46.5）。SCD总体相关主要死因是败血症（32.1%），其次是肺炎（19.4%）和呼吸衰竭（18.2%）。在以SCD为相关死因的死亡证明中，根本死因是循环系统疾病（8.7%），在男性中，其次是消化系统疾病、传染病和呼吸系统衰竭，而在女性中，妊娠、分娩和产褥期章节中的孕产妇死亡占女性死亡的4.6%，其次是消化系统疾病和传染病。
本研究修订了巴西死亡率趋势、根本死因和相关死因、死亡年龄及死亡地区分布的死亡率数据。
