Gilbert T, Nabarra B, Merlet-Bénichou C
Unité de Recherches sur la Prévention et le Traitement des Maladies Infectieuses, INSERM U13, Hôpital Claude Bernard, Paris, France.
Am J Pathol. 1988 Jan;130(1):33-43.
Kidneys of newborn rats, whose mothers were given 75 mg/kg of gentamicin daily from the tenth day of gestation to its term, were examined by light and electron microscopy, as were kidneys of control rats whose mothers were given saline during the same period. In the gentamicin-treated group, the numbers of differentiated glomeruli and of S-shaped bodies counted in a median cross-section of the kidney were reduced, compared with those in the control group, but the glomerular volume was the same. In newborn rats issued from gentamicin-treated mothers, the proximal tubular lumen of the mature nephron lying in the deepest cortex was dilated, and their proximal tubular cells exhibited extensive damage, resembling that described in tubular cells of adult rats exposed to gentamicin. The subcapsular nephrogenic zone exhibited focal alterations of cytoplasmic organelle membranes, as well as nuclear lesions of several types, in cells of the nephron anlagen of the undifferentiated metanephric blastema, which were otherwise of normal appearance.
从妊娠第10天至足月，每天给新生大鼠的母亲注射75毫克/千克庆大霉素，对这些新生大鼠的肾脏进行光镜和电镜检查，同时对同期给母亲注射生理盐水的对照大鼠的肾脏也进行检查。与对照组相比，庆大霉素处理组肾脏的中截面中分化肾小球和S形体的数量减少，但肾小球体积相同。在母亲接受庆大霉素处理的新生大鼠中，位于最深皮质层的成熟肾单位的近端肾小管管腔扩张，其近端肾小管细胞表现出广泛损伤，类似于成年大鼠暴露于庆大霉素后肾小管细胞所描述的损伤。被膜下肾发生区在未分化后肾胚基的肾单位原基细胞中，表现出细胞质细胞器膜的局灶性改变以及几种类型的核损伤，而这些细胞在其他方面外观正常。
