中性粒细胞与淋巴细胞、单核细胞与淋巴细胞以及淋巴细胞与血小板比值对 COVID-19 相关并发症预后的价值。
Usefulness of the neutrophil-to-lymphocyte, monocyte-to-lymphocyte and lymphocyte-to-platelet ratios for the prognosis of COVID-19-associated complications.
机构信息
Department of Internal Medicine, Cuautitlán General Hospital, Instituto de Salud del Estado de México, State of Mexico. Mexico.
Hematology Department, Hospital General de México "Dr. Eduardo Liceaga", Secretaría de Salud. Mexico City. Mexico.
出版信息
Gac Med Mex. 2020;156(5):405-411. doi: 10.24875/GMM.M20000428.
INTRODUCTION
Various biomarkers based on blood counts have been useful for the prognosis of patients critically ill with COVID-19.
OBJECTIVE
To describe the usefulness of the neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR) and lymphocyte-to-platelet (LPR) ratios for the prognosis of mortality and ventilatory support requirement for COVID-19.
METHOD
Retrospective cohort of clinical records of patients with COVID-19 who required hospital care.
RESULTS
One-hundred and -twenty-five cases were analyzed; mean age was 51 years, and 60 % were of the male gender; 21.6 % had type 2 diabetes mellitus, and 18.4 % had hypertension. Mean leukocyte count was 9.5 x 10/µL, with a neutrophil mean of 8.0 x 10/µL. Mean NLR was 12.01, while for MLR it was 0.442, and for LPR, 373.07. Regarding the area under the curve, the following values were recorded for mortality: 0.594 for NLR, 0.628 for MLR and 0.505 for LPR; as for mechanical ventilation, the values were 0.581 for NLR, 0.619 for MLR and 0.547 for LPR. In the univariate analysis, an NLR value > 13 (OR: 2.750, p = 0.001) and an MLR of > 0.5 (OR: 2.069, p = 0.047) were associated with mortality; LPR showed no impact on mortality or respiratory support.
CONCLUSION
NLR and MLR are useful for predicting mortality in patients with COVID-19.
介绍
基于血细胞计数的各种生物标志物已被证明对 COVID-19 危重症患者的预后有用。
目的
描述中性粒细胞与淋巴细胞（NLR）、单核细胞与淋巴细胞（MLR）和淋巴细胞与血小板（LPR）比值对 COVID-19 患者死亡率和通气支持需求的预后价值。
方法
回顾性分析了需要住院治疗的 COVID-19 患者的临床记录。
结果
共分析了 125 例患者，平均年龄为 51 岁，60%为男性；21.6%患有 2 型糖尿病，18.4%患有高血压。平均白细胞计数为 9.5 x 10/µL，中性粒细胞平均为 8.0 x 10/µL。平均 NLR 为 12.01，MLR 为 0.442，LPR 为 373.07。关于曲线下面积，死亡率的记录值如下：NLR 为 0.594，MLR 为 0.628，LPR 为 0.505；对于机械通气，NLR 值为 0.581，MLR 值为 0.619，LPR 值为 0.547。在单因素分析中，NLR 值>13（OR：2.750，p=0.001）和 MLR>0.5（OR：2.069，p=0.047）与死亡率相关；LPR 对死亡率或呼吸支持无影响。
结论
NLR 和 MLR 可用于预测 COVID-19 患者的死亡率。
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