Śliżewska Katarzyna, Markowiak-Kopeć Paulina, Śliżewska Weronika
Institute of Fermentation Technology and Microbiology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczańska 171/173, 90-924 Lodz, Poland.
Institute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Lodz, Poland.
Cancers (Basel). 2020 Dec 23;13(1):20. doi: 10.3390/cancers13010020.
The gut microbiome can play important role in maintaining homeostasis in the human body. An imbalance in the gut microbiome can lead to pro-inflammatory immune responses and the initiation of disease processes, including cancer. The research results prove some strains of probiotics by modulating intestinal microbiota and immune response can be used for cancer prevention or/and as adjuvant treatment during anticancer chemotherapy. This review presents the latest advances in research into the effectiveness of probiotics in the prevention and treatment support of cancer. The described issues concern to the anticancer activity of probiotic microorganisms and their metabolites. In addition, we described the potential mechanisms of probiotic chemoprevention and the advisability of using probiotics.
肠道微生物群在维持人体稳态中可发挥重要作用。肠道微生物群失衡可导致促炎免疫反应以及包括癌症在内的疾病进程的启动。研究结果证明，某些益生菌菌株可通过调节肠道微生物群和免疫反应，用于癌症预防或/及作为抗癌化疗期间的辅助治疗。本综述介绍了益生菌在癌症预防和治疗支持方面有效性研究的最新进展。所描述的问题涉及益生菌微生物及其代谢产物的抗癌活性。此外，我们还描述了益生菌化学预防的潜在机制以及使用益生菌的合理性。
