Schenk Alexander, Esser Tobias, Knoop André, Thevis Mario, Herden Jan, Heidenreich Axel, Bloch Wilhelm, Joisten Niklas, Zimmer Philipp
Institute for Sport and Sport Science, TU-Dortmund, Otto-Hahn-Str. 3, 44227 Dortmund, Germany.
Department of Molecular and Cellular Sport Medicine, Institute for Cardiology and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
Metabolites. 2020 Dec 23;11(1):4. doi: 10.3390/metabo11010004.
The kynurenine (KYN) pathway gains growing research interest concerning the genesis, progression and therapy of solid tumors. Previous studies showed exercise-induced effects on metabolite levels along the KYN pathway. Modulations of the KYN pathway might be involved in the positive impact of exercise on prostate cancer progression and mortality. The objective of this trial was to investigate whether a single-physical exercise alters tryptophan (TRP) metabolism and related inflammatory markers in this population. We conducted a randomized controlled trial with 24 patients suffering from prostate cancer. While the control group remained inactive, the intervention group performed a 30-min aerobic exercise on a bicycle ergometer at 75% of individual VO. Before (t0) and directly after the exercise intervention (t1) KYN, TRP, kynurenic acid, quinolinic acid as well as various inflammation markers (IL6, TNF-α, TGF-β) were measured in blood serum. At baseline, the present sample showed robust correlations between TRP, KYN, quinolinic acid and inflammatory markers. Regarding the exercise intervention, interaction effects for TRP, the KYN/TRP ratio and TGF-β were observed. The results show for the first time that acute physical exercise impacts TRP metabolism in prostate cancer patients. Moreover, baseline associations underline the relationship between inflammation and the KYN pathway in prostate cancer.
犬尿氨酸（KYN）途径在实体瘤的发生、发展和治疗方面越来越受到研究关注。先前的研究表明运动对KYN途径中的代谢物水平有影响。KYN途径的调节可能参与了运动对前列腺癌进展和死亡率的积极影响。本试验的目的是研究单次体育锻炼是否会改变该人群中色氨酸（TRP）的代谢及相关炎症标志物。我们对24名前列腺癌患者进行了一项随机对照试验。对照组保持不运动状态，干预组在自行车测力计上以个人最大摄氧量的75%进行30分钟的有氧运动。在运动干预前（t0）和干预结束后立即（t1），检测血清中的KYN、TRP、犬尿酸、喹啉酸以及各种炎症标志物（IL6、TNF-α、TGF-β）。在基线时，本样本显示TRP、KYN、喹啉酸与炎症标志物之间存在显著相关性。关于运动干预，观察到TRP、KYN/TRP比值和TGF-β的交互作用。结果首次表明急性体育锻炼会影响前列腺癌患者的TRP代谢。此外，基线关联强调了前列腺癌中炎症与KYN途径之间的关系。
