Gomez Juan D, Mayner William G P, Beheler-Amass Maggie, Tononi Giulio, Albantakis Larissa
Department of Psychiatry, Wisconsin Institute for Sleep and Consciousness, University of Wisconsin-Madison, Madison, WI 53719, USA.
Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53719, USA.
Entropy (Basel). 2020 Dec 22;23(1):6. doi: 10.3390/e23010006.
Integrated information theory (IIT) provides a mathematical framework to characterize the cause-effect structure of a physical system and its amount of integrated information (Φ). An accompanying Python software package ("PyPhi") was recently introduced to implement this framework for the causal analysis of discrete dynamical systems of binary elements. Here, we present an update to PyPhi that extends its applicability to systems constituted of discrete, but multi-valued elements. This allows us to analyze and compare general causal properties of random networks made up of binary, ternary, quaternary, and mixed nodes. Moreover, we apply the developed tools for causal analysis to a simple non-binary regulatory network model (p53-Mdm2) and discuss commonly used binarization methods in light of their capacity to preserve the causal structure of the original system with multi-valued elements.
整合信息理论(IIT)提供了一个数学框架,用于刻画物理系统的因果结构及其整合信息量(Φ)。最近引入了一个配套的Python软件包(“PyPhi”),以实现该框架用于对二元元素离散动力系统进行因果分析。在此,我们展示了对PyPhi的一次更新,将其适用性扩展到由离散但多值元素构成的系统。这使我们能够分析和比较由二元、三元、四元及混合节点组成的随机网络的一般因果特性。此外,我们将所开发的因果分析工具应用于一个简单的非二元调控网络模型(p53-Mdm2),并根据常用的二值化方法保留具有多值元素的原始系统因果结构的能力进行讨论。