Central Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian 116001, People's Republic of China.
Institute (College) Integrative Medicine, Dalian Medical University, Dalian 116044, People's Republic of China.
Drug Des Devel Ther. 2020 Dec 22;14:5623-5632. doi: 10.2147/DDDT.S260703. eCollection 2020.
Paeoniflorin is a main active component in traditional Chinese medicine. Paeoniae alba radix is widely used as a spasmolytic and pain-relieving agent for abdominal spasmodic pain. Functional dyspepsia (FD) is characterized by pain or burning in the epigastrium, fullness, bloating and nausea. However, limited information is available about the effect of paeoniflorin on FD.
In this study, iodoacetamide or clonidine-induced FD rat models were established to investigate the impacts of paeoniflorin on FD induced by different pathophysiologic disturbances.
We found the therapeutic effect of paeoniflorin through assessing the gastric emptying, gastric accommodation and visceral hypersensitivity. This function of paeoniflorin was related to the release of acetylcholine (ACh), which was accompanied by reduced acetylcholinesterase (AchE) activity in stomach and hypothalamus. Paeoniflorin administration inhibited the cyclo-oxygenase-2 (COX-2) expression and increased the level of ghrelin in the stomach. Besides, the levels of occludin and ZO-1 were elevated in the duodenum from paeoniflorin-treated rats, suggesting the impaired duodenal barrier was ameliorated.
These results indicate that paeoniflorin possesses the ability to alleviate functional dyspepsia.
芍药苷是中药的主要活性成分。白芍被广泛用作缓解腹部痉挛性疼痛的解痉和止痛剂。功能性消化不良（FD）的特征是上腹痛、饱胀、腹胀和恶心。然而，关于芍药苷对 FD 的影响的信息有限。
本研究建立了碘乙酰胺或可乐定诱导的 FD 大鼠模型，以研究芍药苷对不同病理生理紊乱引起的 FD 的影响。
我们通过评估胃排空、胃容纳和内脏敏感性来发现芍药苷的治疗效果。芍药苷的这种作用与乙酰胆碱（ACh）的释放有关，同时伴随着胃和下丘脑乙酰胆碱酯酶（AchE）活性的降低。芍药苷给药抑制环加氧酶-2（COX-2）的表达，并增加胃中胃饥饿素的水平。此外，芍药苷处理大鼠的十二指肠中闭合蛋白和 ZO-1 的水平升高，表明受损的十二指肠屏障得到改善。
这些结果表明，芍药苷具有缓解功能性消化不良的能力。
