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孕期咖啡和茶的摄入量与早产之间的关联:病例对照研究

The Association Between Coffee and Tea Consumption During Pregnancy and Preterm Delivery: Case-Control Study.

作者信息

Sindiani Amer Mahmoud, Khader Yousef, Amarin Zouhair

机构信息

Department of Obstetrics and Gynecology, Jordan University of Science and Technology, Irbid, Jordan.

Department of Public Health and Community Medicine, Jordan University of Science and Technology, Irbid, Jordan.

出版信息

J Multidiscip Healthc. 2020 Dec 22;13:2011-2019. doi: 10.2147/JMDH.S286243. eCollection 2020.

Abstract

OBJECTIVE

To assess a possible association between coffee and tea consumption and preterm delivery.

METHODS

A case-control design was implemented on a sample of women who were admitted for delivery to a tertiary hospital in the north of Jordan. Three hundred and fourteen cases and 796 controls were evaluated. The study was conducted while women were in the hospital for delivery. They were questioned about coffee and tea consumption and relevant confounding factors. Women were asked to state the average number of coffee and tea cups they drank per day.

RESULTS

The mean coffee consumption among women with preterm delivery was 0.75 cups/day ±1.23 and the mean tea consumption was 1.47 cups/day± 1.76. Multivariable logistic analysis revealed that increased age (OR=1.05; CI=1.02-1.08), parity (OR=3.82, CI=2.58-5.64), history of abortions (OR=1.69; CI=1.21-2.35), family history of preterm deliveries (OR=2.45, CI=1.33-4.52), having treatment for subfertility (OR=12.14, CI=2.39-61.62), diabetes mellitus (OR=2.22, CI=1.06-4.66), worsened emotional status during pregnancy (OR=2.35, CI=1.49-3.72), short inter-pregnancy interval (OR=1.72, CI=1.10-2.72), no iron consumption (OR=1.46, CI=1.06-2.03), using folic acid (OR=2.45, CI=1.33-4.52), and black colour women (OR=2.87, CI=1.35-6.10) were predictive for preterm delivery. After controlling for all significant predictors, coffee and tea consumption during pregnancy was not significantly associated with increased odds of preterm delivery.

CONCLUSION

These results do not support an association between coffee and tea consumption and preterm delivery.

摘要

目的

评估咖啡和茶的摄入量与早产之间可能存在的关联。

方法

对约旦北部一家三级医院收治的分娩女性样本采用病例对照设计。评估了314例病例和796例对照。该研究在女性住院分娩期间进行。询问了她们咖啡和茶的摄入量以及相关混杂因素。要求女性说出她们每天饮用咖啡和茶的平均杯数。

结果

早产女性的平均咖啡摄入量为0.75杯/天±1.23,平均茶摄入量为1.47杯/天±1.76。多变量逻辑分析显示,年龄增加(比值比[OR]=1.05;置信区间[CI]=1.02 - 1.08)、产次(OR=3.82,CI=2.58 - 5.64)、流产史(OR=1.69;CI=1.21 - 2.35)、早产家族史(OR=2.45,CI=1.33 - 4.52)、接受过不育治疗(OR=12.14,CI=2.39 - 61.62)、糖尿病(OR=2.22,CI=1.06 - 4.66)、孕期情绪状态恶化(OR=2.35,CI=1.49 - 3.72)、妊娠间隔短(OR=1.72,CI=1.10 - 2.72)、未摄入铁剂(OR=1.46,CI=1.06 - 2.03)、使用叶酸(OR=2.45,CI=1.33 - 4.52)以及黑人女性(OR=2.87,CI=1.35 - 6.10)是早产的预测因素。在控制了所有显著预测因素后,孕期咖啡和茶的摄入量与早产几率增加无显著关联。

结论

这些结果不支持咖啡和茶的摄入量与早产之间存在关联。

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本文引用的文献

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Folic Acid and Risk of Preterm Birth: A Meta-Analysis.叶酸与早产风险:一项荟萃分析
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The Safety of Ingested Caffeine: A Comprehensive Review.摄入咖啡因的安全性:全面综述
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