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南非东开普省阿马托勒区部分农村社区腹泻患者中产腹泻性大肠埃希菌（DEC）及分离菌株的抗菌药物耐药谱

Antimicrobial Resistance Profiles of Diarrheagenic (DEC) and Species Recovered from Diarrheal Patients in Selected Rural Communities of the Amathole District Municipality, Eastern Cape Province, South Africa.

作者信息

Msolo Luyanda, Iweriebor Benson C, Okoh Anthony I

机构信息

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, Eastern Cape, South Africa.

Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, Eastern Cape, South Africa.

出版信息

Infect Drug Resist. 2020 Dec 22;13:4615-4626. doi: 10.2147/IDR.S269219. eCollection 2020.

DOI:10.2147/IDR.S269219
PMID:33376367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7764871/
Abstract

PURPOSE

The emergence of multidrug-resistant bacteria remains as one of the major impediments towards the prevention and treatment of microbial infections and continues to be a serious threat to medicine. Henceforth, this study aimed at elucidating the antimicrobial resistance profiles of diarrheagenic (DEC) and species recovered from diarrheal patients in selected rural communities of the Amathole District Municipality (ADM), Eastern Cape Province, South Africa (SA).

METHODS

The antimicrobial resistance profiles of diarrheagenic and isolates were evaluated using antimicrobial susceptibility tests and the relevant antimicrobial resistance factors were elucidated by the Polymerase Chain Reaction technique.

RESULTS

A sum of 324 diarrheagenic and 62 isolates were recovered from diarrheal stool specimens collected amongst diarrheal patients admitted in medical facilities/health-care centers within the ADM in the Eastern Cape Province, South Africa. Multiple antimicrobial resistance index mean values of 0.7 and 0.5 for DEC and isolates, respectively, were observed in this study, indicating that these isolates were from sources where antimicrobials were frequently used. The antimicrobial resistance factors I and II, A and A were detected among antimicrobial-resistant DEC pathotypes and isolates recovered in this study.

CONCLUSION

The occurrence of the multiple antimicrobial-resistant DEC and isolates with the relevant antimicrobial resistance factors in this study suggests a portentous human health threat associated with diarrhea and a major deterrent in medicine.

摘要

目的

多重耐药细菌的出现仍然是预防和治疗微生物感染的主要障碍之一，并且仍然是医学面临的严重威胁。因此，本研究旨在阐明从南非东开普省阿马托勒区市（ADM）选定农村社区腹泻患者中分离出的致泻性（DEC）菌和[具体菌种]的抗菌药物耐药谱。

方法

使用抗菌药物敏感性试验评估致泻性菌和[具体菌种]分离株的抗菌药物耐药谱，并通过聚合酶链反应技术阐明相关的抗菌药物耐药因素。

结果

从南非东开普省ADM内医疗设施/医疗保健中心收治的腹泻患者的腹泻粪便标本中，共分离出324株致泻性菌和62株[具体菌种]分离株。本研究中观察到DEC和[具体菌种]分离株的多重抗菌药物耐药指数平均值分别为0.7和0.5，表明这些分离株来自经常使用抗菌药物的来源。在本研究中分离出的抗菌药物耐药DEC致病型和[具体菌种]分离株中检测到抗菌药物耐药因素I和II、[具体因素A]和[具体因素A]。

结论

本研究中出现的具有相关抗菌药物耐药因素的多重抗菌药物耐药DEC和[具体菌种]分离株表明，腹泻对人类健康构成严重威胁，并且是医学上的一大阻碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/815e2935a185/IDR-13-4615-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/eb1889044b44/IDR-13-4615-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/8fe816531026/IDR-13-4615-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/c0895a86ad16/IDR-13-4615-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/596575d4df09/IDR-13-4615-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/433111ab53ff/IDR-13-4615-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/815e2935a185/IDR-13-4615-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/eb1889044b44/IDR-13-4615-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/8718becebf55/IDR-13-4615-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/c0895a86ad16/IDR-13-4615-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/596575d4df09/IDR-13-4615-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/433111ab53ff/IDR-13-4615-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db72/7764871/815e2935a185/IDR-13-4615-g0008.jpg

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