Ramatla Tsepo, Tawana Mpho, Lekota Kgaugelo E, Thekisoe Oriel
Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa.
AIMS Microbiol. 2023 Feb 13;9(1):75-89. doi: 10.3934/microbiol.2023005. eCollection 2023.
This is a systematic review and meta-analysis that evaluated the prevalence of antibiotic-resistant genes (ARGs) in animals, humans, and the environment in South Africa. This study followed Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines to search and use literature published between 1 January 2000 to 12 December 2021, on the prevalence of South African isolates' ARGs. Articles were downloaded from African Journals Online, PubMed, ScienceDirect, Scopus, and Google Scholar search engines. A random effects meta-analysis was used to estimate the antibiotic-resistant genes of in animals, humans, and the environment. Out of 10764 published articles, only 23 studies met the inclusion criteria. The obtained results indicated that the pooled prevalence estimates (PPE) of . ARGs was 36.3%, 34.4%, 32.9%, and 28.8% for , C, A, and , respectively. Eight ARGs ( , , , A, B, 1, II, and A) were detected in humans, animals and the environmental samples. Human isolate samples harboured 38% of the ARGs. Analyzed data from this study highlights the occurrence of ARGs in isolates from animals, humans, and environmental samples in South Africa. Therefore, there is a necessity to develop a comprehensive "One Health" strategy to assess antibiotics use in order to understand the causes and dynamics of antibiotic resistance development, as such information will enable the formulation of intervention strategies to stop the spread of ARGs in the future.
这是一项系统评价和荟萃分析，评估了南非动物、人类和环境中抗生素抗性基因（ARGs）的流行情况。本研究遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南，检索并使用了2000年1月1日至2021年12月12日期间发表的关于南非分离株ARGs流行情况的文献。文章从非洲在线期刊、PubMed、ScienceDirect、Scopus和谷歌学术搜索引擎下载。采用随机效应荟萃分析来估计动物、人类和环境中的抗生素抗性基因。在10764篇已发表的文章中，只有23项研究符合纳入标准。获得的结果表明，对于……，ARGs的合并流行率估计值（PPE）分别为36.3%、34.4%、32.9%和28.8%。在人类、动物和环境样本中检测到8种ARGs（……）。人类分离株样本中含有38%的ARGs。本研究分析的数据突出了南非动物、人类和环境样本分离株中ARGs的存在。因此，有必要制定一项全面的“同一健康”战略来评估抗生素的使用，以了解抗生素耐药性发展的原因和动态，因为这些信息将有助于制定干预策略，以阻止未来ARGs的传播。
