Chen Xueqin, Wu Caiming, Liang Wen'na, Shen Jianying, Zhuo Zewei, Hu Liu, Ruan Luwei, Zhang Pengheng, Xu Leqin, Li Chengfu, Lin Shengyuan, Lan Junjie, Ren Haixia, Yao Hongwei, Zhao Tongjin, Gao Bizhen, Lin Tianwei, Huang Huiying, Li Candong
The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361026, China.
Xiamen Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, Xiamen, China.
Evid Based Complement Alternat Med. 2020 Dec 9;2020:8568353. doi: 10.1155/2020/8568353. eCollection 2020.
Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. . By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols.
With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by H NMR.
H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age.
The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body's metabolic states to alleviate symptoms of the disorder.
在中医诊断分层体系中，传统中医通常将围绝经期综合征（PMS）的病因病机归为肾虚。然而，这一经典归因的分子基础仍有待研究。通过揭示对肾虚的中医治疗反应，可以评估PMS与肾虚之间的代谢组学联系，以便深入了解中医治疗机制并制定更好的治疗方案。
以自然衰老大鼠作为PMS模型，采用核磁共振氢谱（H NMR）研究对肾虚的中医治疗的代谢组学反应。
血浆样本的核磁共振氢谱代谢组学证据表明，用两种经典的补肾中药方剂右归丸和左归丸水煎剂治疗，可使疾病模型的代谢状态向年轻大鼠的代谢状态转变。
数据支持以下观点，即肾虚至少在一定程度上导致PMS，相关方剂有助于减轻身体代谢状态的变化，从而缓解该病症的症状。
