Xiang Ke-Zhen, Chen Liang, Yang De-Qin
Oral Hospital Affiliated to Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedicine, Key Laboratory of Oral Biomedical Engineering in Chongqing Universities, Chongqing 401147, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Dec 1;38(6):692-696. doi: 10.7518/hxkq.2020.06.015.
Polyamide-amine (PAMAM) dendrimer, a new hyperbranched macromolecular polymer, is considered an "artificial protein" by many scholars on account of its excellent chemical and biological characteristics. PAMAM has internal cavities and a large number of reactive terminal groups. These structures allow the polymer to be used as a bionic macromoleculethat could simulate the biomimetic mineralization of the natural organic matrix on the surface of tooth tissue. Specifically, PAMAM can beused as an organic template to regulate mineral nucleation and crystal growth; thus, the polymerisa more ideal dental restoration material than traditional allogenic materials. This article reviews research progress on thePAMAM-induced biomimetic mineralization of hard tooth tissues.
聚酰胺 - 胺（PAMAM）树枝状大分子是一种新型的超支化高分子聚合物，因其优异的化学和生物学特性，被许多学者视为“人工蛋白质”。PAMAM具有内部空腔和大量的活性端基。这些结构使得该聚合物能够用作仿生大分子，模拟牙齿组织表面天然有机基质的仿生矿化。具体而言，PAMAM可用作有机模板来调节矿物成核和晶体生长；因此，与传统的同种异体材料相比，该聚合物是一种更理想的牙齿修复材料。本文综述了PAMAM诱导硬齿组织仿生矿化的研究进展。
