Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):12844-12848. doi: 10.26355/eurrev_202012_24186.
To explore the correlation of the growth differentiation factor-15 (GDF-15) with the severity of chronic heart failure (CHF) in patients with coronary atherosclerosis.
300 coronary atherosclerosis patients with CHF treated in our hospital from January 2019 to December 2019 and 300 healthy people (control group) were collected and retrospectively analyzed. The basic clinical information of the patients, such as age, gender, smoking/drinking history, waist-hip ratio, BMI and blood lipid were collected, and GDF-15, cystatin C and c-reactive protein (CRP) were determined. The severity of heart failure was classified.
No significant differences in clinical information were found such as age, gender, smoking/drinking history, waist-to-hip ratio, BMI and blood lipid. However, there were significant differences in GDF-15, cystatin C and CRP among patients with different severities of heart failure. The GDF-15 level was 582.6 ± 104.4 pg/ml in patients with grade IV heart failure and 408.4 ± 94.8 pg/ml in patients with grade I heart failure. There was a significance after GDF-15, cystatin C and CRP were adjusted (p = 0.03) and also after the clinical information and GDF-15 were adjusted (p < 0.001).
GDF-15 level is correlated with the CHF severity in patients with coronary atherosclerosis, indicating that it is a potential index to evaluate the CHF severity, providing clues to the biological mechanism and treatment of heart failure.
探讨生长分化因子 15（GDF-15）与冠状动脉粥样硬化患者慢性心力衰竭（CHF）严重程度的相关性。
收集我院 2019 年 1 月至 2019 年 12 月收治的 300 例冠状动脉粥样硬化合并 CHF 患者（观察组）和同期 300 例健康体检者（对照组）的临床资料，回顾性分析患者的基本临床资料，如年龄、性别、吸烟/饮酒史、腰臀比、BMI 及血脂等，测定 GDF-15、胱抑素 C 及 C 反应蛋白（CRP），并对心力衰竭严重程度进行分级。
观察组患者的年龄、性别、吸烟/饮酒史、腰臀比、BMI 及血脂等一般资料比较，差异无统计学意义（P＞0.05）；但不同心力衰竭严重程度患者的 GDF-15、胱抑素 C 及 CRP 比较，差异均有统计学意义（P＜0.05）。其中，心功能Ⅳ级患者的 GDF-15 水平为（582.6±104.4）pg/ml，心功能Ⅰ级患者的 GDF-15 水平为（408.4±94.8）pg/ml，差异有统计学意义（P＜0.05）。校正 GDF-15、胱抑素 C 及 CRP 后，差异有统计学意义（P=0.03）；校正临床资料及 GDF-15 后，差异有统计学意义（P＜0.001）。
GDF-15 水平与冠状动脉粥样硬化患者 CHF 严重程度相关，提示其可能成为评估 CHF 严重程度的潜在指标，为心力衰竭的生物学机制及治疗提供线索。
