Phadnaik Mangesh B, Attar Nilofar
Department of Periodontics, Government Dental College and Hospital, Aurangabad - 431 001, Maharashtra, India.
Indian J Dent Res. 2010 Jul-Sep;21(3):460-2. doi: 10.4103/0970-9290.70788.
Plasma cell granuloma is a rare reactive lesion composed of polyclonal plasma cells. It manifests primarily in the lungs, but may occur in various other anatomic locations like the oral cavity. Intraoral plasma cell granulomas involving the tongue, lip, oral mucosa and gingiva have been reported in the past. This case presents a 54-year-old female with chronic periodontitis and mandibular anterior gingival overgrowth treated by Phase I therapy (scaling and root planing) and excisional biopsy. Histological examination revealed inflammatory cell infiltrate containing sheets of plasma cells. Immunohistochemistry for kappa and lambda light chains showed a polyclonal staining pattern confirming a diagnosis of plasma cell granuloma. This case highlights the need to biopsy for unusual lesions to rule out potential neoplasms.
浆细胞性肉芽肿是一种由多克隆浆细胞组成的罕见反应性病变。它主要表现在肺部，但也可能发生在其他各种解剖部位，如口腔。过去曾有报道口腔内的浆细胞性肉芽肿累及舌、唇、口腔黏膜和牙龈。本病例为一名54岁女性，患有慢性牙周炎和下颌前牙牙龈增生，接受了第一阶段治疗（洁治和根面平整）及切除活检。组织学检查显示有含大量浆细胞的炎性细胞浸润。κ和λ轻链的免疫组化显示多克隆染色模式，确诊为浆细胞性肉芽肿。本病例强调了对不寻常病变进行活检以排除潜在肿瘤的必要性。
