Department of Periodontology, Faculty of Dentistry, Kirikkale University, Kirikkale, Turkey.
Department of Biochemistry, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Aust Dent J. 2021 Jun;66(2):169-174. doi: 10.1111/adj.12815. Epub 2021 Jan 19.
The aim of study was to evaluate galectin-3 levels in gingival crevicular fluid (GCF) from periodontally healthy (H) patients and those with periodontitis (P), gingivitis (G) and the effect of initial periodontal treatment on GCF galectin-3 level.
A total of 75 participants, 25 patients with periodontitis, 25 with gingivitis and 25 periodontally healthy subjects were included into the study. Patients with periodontal disease received initial periodontal treatment. GCF galectin-3 level was assessed at baseline and at the 6th-8th weeks after completion of periodontal treatment. GCF galectin-3 level was evaluated by enzyme-linked immunosorbent assay.
GCF galectin-3 level was the lowest in the H group (102.31[63.07] μg/30 s), followed by the G group (241.45[145.89] μg/30 s) and the highest in the P group (338.27[219.37] μg/30 s). These differences were statistically significant between H and the other groups (P < 0.001). After initial periodontal treatment, GCF galectin-3 level significantly decreased in the G and P groups compared to baseline values (P < 0.01).
The results of this study suggest that GCF galectin-3 level is a potential biomarker for the evaluation of gingival inflammation and initial periodontal treatment is effective in decreasing GCF galectin-3 level.
本研究旨在评估牙周健康（H）患者和牙周炎（P）、牙龈炎（G）患者龈沟液（GCF）中的半乳糖凝集素-3（Gal-3）水平，以及初始牙周治疗对 GCF Gal-3 水平的影响。
共纳入 75 名参与者，其中牙周炎患者 25 例，牙龈炎患者 25 例，牙周健康者 25 例。牙周病患者接受初始牙周治疗。在基线和牙周治疗结束后第 6-8 周评估 GCF Gal-3 水平。采用酶联免疫吸附试验（ELISA）评估 GCF Gal-3 水平。
GCF Gal-3 水平在 H 组最低（102.31[63.07]μg/30s），其次是 G 组（241.45[145.89]μg/30s），最高的是 P 组（338.27[219.37]μg/30s）。H 组与其他两组之间的差异有统计学意义（P<0.001）。初始牙周治疗后，G 和 P 组 GCF Gal-3 水平与基线值相比显著降低（P<0.01）。
本研究结果提示，GCF Gal-3 水平可能是评估牙龈炎症的潜在生物标志物，初始牙周治疗可有效降低 GCF Gal-3 水平。
