血清半乳糖凝集素-3 与 2 型糖尿病患者牙周炎的关系。
Association between serum Galectin-3 and periodontitis in patients with type 2 diabetes mellitus.
机构信息
Dept. of Periodontology, School of Stomatology, Weifang Medical College, Weifang 261053, China.
Dept. of Stomatology, Weifang People's Hospital, Affiliated to Weifang Medical College, Weifang 261042, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2023 Dec 1;41(6):653-661. doi: 10.7518/hxkq.2023.2023192.
OBJECTIVES
This study aims to investigate the correlation between serum Galectin-3 levels and the risk of periodontitis in patients with type 2 diabetes mellitus (T2DM).
METHODS
A total of 140 patients with T2DM admitted to the endocrinology department of Weifang People's Hospital, Affiliated to Weifang Medical College from July 2021 to November 2022 were selected and divided into T2DM without periodontitis group (T2DM group, =67) and T2DM with periodontitis group (T2DMP group, =73) according to whether they were combined with periodontitis. In the same period, 65 non-periodontitis volunteers with normal blood glucose were selected as healthy control group (NC group). Blood samples of all subjects were collected, and serum Galectin-3 levels and related laboratory indices were detected and compared among the three groups.
RESULTS
Serum Galectin-3 levels in the NC, T2DM, and T2DMP groups were 3.81 (3.49, 4.15), 4.82 (4.25, 5.26), and 6.83 (5.19, 7.28) ng/mL, respectively. After adjusting for the influence of baseline data by multiple linear regression, serum Galectin-3 levels in the T2DMP and T2DM groups were significantly higher than those in the NC group (all <0.05). Multiple linear regression analysis showed that serum Galectin-3 levels were positively correlated with homeostatic model of the insulin resistance index (=0.254, 95%CI:0.089-0.419, =0.003), glycosylated hemoglobin A1c (=0.397, 95%CI: 0.049-0.745, =0.026), and clinical attachment loss (=0.298, 95%CI: 0.024-0.572, =0.033). After adjusting for the effects of covariates, binary logistic regression showed that serum Galectin-3 levels were significantly associated with the risk of periodontitis in patients with T2DM (OR=2.146, 95%CI: 1.260-3.655, =0.005). Trend test showed that the risk of periodontitis in patients with T2DM increased with increasing serum Galectin-3 levels (=0.011). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of serum Galectin-3 in predicting T2DM periodontitis was 0.861 (95%CI: 0.801-0.920, =11.806, <0.001).
CONCLUSIONS
Serum Galectin-3 levels were elevated in patients with T2DM and pe-riodontitis and associated with the risk of periodontitis.
目的
本研究旨在探讨血清半乳糖凝集素-3（Galectin-3）水平与 2 型糖尿病（T2DM）患者牙周炎风险的相关性。
方法
选取 2021 年 7 月至 2022 年 11 月潍坊医学院附属潍坊市人民医院内分泌科收治的 140 例 T2DM 患者，根据是否合并牙周炎分为 T2DM 无牙周炎组（T2DM 组，n=67）和 T2DM 合并牙周炎组（T2DMP 组，n=73）。同期选取 65 例血糖正常的非牙周炎志愿者作为健康对照组（NC 组）。采集所有受试者的血样，检测并比较三组的血清 Galectin-3 水平及相关实验室指标。
结果
NC、T2DM 和 T2DMP 组的血清 Galectin-3 水平分别为 3.81（3.49，4.15）、4.82（4.25，5.26）和 6.83（5.19，7.28）ng/mL。经多线性回归校正基线数据影响后，T2DMP 组和 T2DM 组的血清 Galectin-3 水平均明显高于 NC 组（均<0.05）。多线性回归分析显示，血清 Galectin-3 水平与稳态模型评估的胰岛素抵抗指数（HOMA-IR）呈正相关（β=0.254，95%CI：0.0890.419，=0.003），与糖化血红蛋白 A1c（HbA1c）呈正相关（β=0.397，95%CI：0.0490.745，=0.026），与临床附着丧失呈正相关（β=0.298，95%CI：0.0240.572，=0.033）。校正协变量影响后，二项逻辑回归显示，血清 Galectin-3 水平与 T2DM 患者牙周炎的发病风险显著相关（OR=2.146，95%CI：1.2603.655，=0.005）。趋势检验显示，T2DM 患者牙周炎的发病风险随血清 Galectin-3 水平的升高而增加（=0.011）。受试者工作特征（ROC）曲线分析显示，血清 Galectin-3 预测 T2DM 牙周炎的曲线下面积（AUC）为 0.861（95%CI：0.801~0.920，=11.806，<0.001）。
结论
T2DM 伴牙周炎患者血清 Galectin-3 水平升高，与牙周炎发病风险相关。
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