Chichkanov G G, Tsorin I B, Kirsanova G Iu, Lomtadze D M
Biull Eksp Biol Med. 1988 Jan;105(1):46-8.
In the experiments on different animal species (mice, cats, dogs) lithium hydroxybutyrate has been shown to have antihypoxic and anti-ischemic effects. Lithium hydroxybutyrate improved the functional state of the ischemic myocardium, stimulated the accumulation of macroergic phosphates (ATP) in the heart, protected the ischemic myocardium and delayed the progression of the reversible ischemic damage into the irreversible one. The improvement of the collateral coronary circulation plays an important role in the anti-ischemic action of the drug.
在针对不同动物物种（小鼠、猫、狗）的实验中，已证实羟基丁酸锂具有抗缺氧和抗缺血作用。羟基丁酸锂改善了缺血心肌的功能状态，刺激了心脏中高能磷酸盐（ATP）的积累，保护了缺血心肌，并延缓了可逆性缺血损伤向不可逆损伤的进展。冠状动脉侧支循环的改善在该药物的抗缺血作用中起着重要作用。
