Yeh Chung-Min, Lee Yi-Ju, Ko Po-Yun, Lin Yueh-Min, Sung Wen-Wei
Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan.
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan.
Medicina (Kaunas). 2020 Dec 28;57(1):17. doi: 10.3390/medicina57010017.
Krüppel-like transcription factor 10 (KLF10) plays a vital role in regulating cell proliferation, including the anti-proliferative process, activation of apoptosis, and differentiation control. KLF10 may also act as a protective factor against oral cancer. We studied the impact of KLF10 expression on the clinical outcomes of oral cancer patients to identify its role as a prognostic factor in oral cancer.
KLF10 immunoreactivity was analyzed by immunohistochemical (IHC) stain analysis in 286 cancer specimens from primary oral cancer patients. The prognostic value of KLF10 on overall survival was determined by Kaplan-Meier analysis and the Cox proportional hazard model.
High KLF10 expression was significantly associated with male gender and betel quid chewing. The 5-year survival rate was greater for patients with high KLF10 expression than for those with low KLF10 expression (62.5% vs. 51.3%, respectively; = 0.005), and multivariate analyses showed that high KLF10 expression was the only independent factor correlated with greater overall patient survival. The significant correlation between high KLF10 expression and a higher 5-year survival rate was observed in certain subgroups of clinical parameters, including female gender, non-smokers, cancer stage T1, and cancer stage N0.
KLF10 expression, detected by IHC staining, could be an independent prognostic marker for oral cancer patients.
Krüppel样转录因子10（KLF10）在调节细胞增殖中发挥着至关重要的作用，包括抗增殖过程、凋亡激活和分化控制。KLF10也可能作为口腔癌的保护因子。我们研究了KLF10表达对口腔癌患者临床结局的影响，以确定其作为口腔癌预后因素的作用。
通过免疫组织化学（IHC）染色分析对286例原发性口腔癌患者的癌组织标本进行KLF10免疫反应性分析。采用Kaplan-Meier分析和Cox比例风险模型确定KLF10对总生存期的预后价值。
KLF10高表达与男性性别和嚼槟榔显著相关。KLF10高表达患者的5年生存率高于KLF10低表达患者（分别为62.5%和51.3%；P = 0.005），多因素分析显示KLF10高表达是与患者总体生存期延长相关的唯一独立因素。在某些临床参数亚组中，包括女性性别、非吸烟者、癌症分期T1和癌症分期N0，观察到KLF10高表达与较高的5年生存率之间存在显著相关性。
通过IHC染色检测到的KLF10表达可能是口腔癌患者的独立预后标志物。
