Nair M K, Sankaranarayanan R, Padmanabhan T K, Madhu C S
Regional Cancer Centre, Medical College Campus, Trivandrum, Kerala, India.
Cancer. 1988 Feb 1;61(3):458-61. doi: 10.1002/1097-0142(19880201)61:3<458::aid-cncr2820610309>3.0.co;2-t.
Fifty-two cases of oral verrucous carcinoma treated with radiotherapy at the Regional Cancer Centre, Trivandrum, Kerala, India in 1982 were evaluated to determine the distribution within the oral cavity, clinical extent, and effectiveness of radiotherapy in controlling the disease. The most common site was the buccal mucosa. Fifty percent of the patients had clinically negative regional lymph nodes and 33% were in earlier stages (T1, T2, N0, and M0). The overall 3-year no evidence of disease (NED) survival rate was 44%. The 3-year NED survival rate with radium implant was 86%. We cannot comment on anaplastic transformation after radiotherapy because our treatment failures have not been subjected for biopsy concerning this matter. Because the results are comparable with those of well-differentiated squamous cell carcinoma, we think that the treatment policies advocated for oral squamous cell carcinoma are also applicable to oral verrucous carcinoma.
1982年，印度喀拉拉邦特里凡得琅地区癌症中心对52例接受放射治疗的口腔疣状癌患者进行了评估，以确定口腔内的分布情况、临床范围以及放射治疗控制该病的有效性。最常见的部位是颊黏膜。50%的患者临床区域淋巴结阴性，33%处于早期阶段（T1、T2、N0和M0）。总体3年无疾病证据（NED）生存率为44%。镭植入的3年NED生存率为86%。我们无法对放疗后的间变转化进行评论，因为我们的治疗失败病例尚未就此进行活检。由于结果与高分化鳞状细胞癌的结果相当，我们认为口腔鳞状细胞癌所倡导的治疗策略也适用于口腔疣状癌。
