Johnson M R, McPherson D D, Fleagle S R, Hunt M M, Hiratzka L F, Kerber R E, Marcus M L, Collins S M, Skorton D J
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City 52242.
Circulation. 1988 Feb;77(2):328-36. doi: 10.1161/01.cir.77.2.328.
Videodensitometry is a nongeometric method of coronary angiographic analysis that can be used to provide an index of coronary luminal area. However, there are few direct studies in vivo of the relationship of videodensitometric data to independent measures of luminal area in humans. Although videodensitometry is theoretically independent of angiographic projection and luminal shape, validation of these assumptions in vivo is also limited. We therefore used intraoperative high-frequency epicardial echocardiography, a technique that can directly determine human coronary luminal area and shape in vivo, to further validate videodensitometry. A total of 36 arterial segments in the left anterior descending and right coronary arteries were studied by videodensitometry and high-frequency echocardiography. Videodensitometry was performed on angiograms in which the arterial segment of interest was not markedly foreshortened and was uniformly filled with contrast. In 22 discrete lesions (13 with circular lumens and nine with oval or complex lumens), videodensitometric and echocardiographic measures of luminal area correlated well (r = .86). In 33 coronary arterial segments, the effect of angiographic projection on videodensitometry was determined by comparison of the results of videodensitometry performed on left anterior oblique vs right anterior oblique angiograms of the segments. Here too, the correlation was good (r = .94, y = 1.04x + 0.002). The good correlation of left anterior oblique with right anterior oblique videodensitometric results held true for lesions with circular and oval or complex lumens. This study further validates the ability of videodensitometry to provide an index of coronary luminal area and confirms in vivo previous assumptions that the results of videodensitometric analysis are independent of angiographic projection and luminal shape.
视频密度测定法是一种冠状动脉造影分析的非几何学方法，可用于提供冠状动脉管腔面积的指标。然而，在人体中，关于视频密度测定数据与管腔面积独立测量值之间关系的直接体内研究很少。尽管从理论上讲，视频密度测定法独立于血管造影投影和管腔形状，但这些假设在体内的验证也很有限。因此，我们使用术中高频心外膜超声心动图（一种可在体内直接确定人体冠状动脉管腔面积和形状的技术）来进一步验证视频密度测定法。通过视频密度测定法和高频超声心动图对左前降支和右冠状动脉的总共36个动脉节段进行了研究。在感兴趣的动脉节段未明显缩短且均匀充满造影剂的血管造影上进行视频密度测定。在22个离散病变（13个管腔呈圆形，9个管腔呈椭圆形或复杂形状）中，管腔面积的视频密度测定值与超声心动图测量值相关性良好（r = 0.86）。在33个冠状动脉节段中，通过比较在节段的左前斜位与右前斜位血管造影上进行的视频密度测定结果，确定了血管造影投影对视频密度测定法的影响。此处相关性也良好（r = 0.94，y = 1.04x + 0.002）。左前斜位与右前斜位视频密度测定结果的良好相关性在管腔呈圆形、椭圆形或复杂形状的病变中均成立。本研究进一步验证了视频密度测定法提供冠状动脉管腔面积指标的能力，并在体内证实了先前的假设，即视频密度测定分析结果独立于血管造影投影和管腔形状。
