Int J Sports Physiol Perform. 2021 Apr 1;16(4):464-473. doi: 10.1123/ijspp.2020-0677. Epub 2021 Jan 12.
Capsaicinoids and capsinoids (CAP) are natural substances found primarily in chili peppers and other spicy foods that agonize the transient receptor potential vanilloid-1 in the mouth, stomach, and small intestine. Several studies have shown CAP to be a potential antiobesity agent and to exhibit an analgesic effect in both rodents and humans. However, there is no scientific consensus about the effects of CAP on physical exercise performance and its physiological mechanisms of action.
This systematic review aimed to better elucidate the effects of CAP compounds as ergogenic aids and to discuss underlying mechanisms of action by which this supplement may potentially enhance endurance performance and muscular strength.
Among 22 studies included in the review, 14 examined the effects of capsaicinoid or capsinoid compounds on endurance and resistance exercise performance in animals, with 9 studies showing benefits on performance. In humans, 8 studies were included: 3 demonstrated significant acute endurance benefits and 2 showed acute resistance exercise performance benefits compared with a placebo condition. Therefore, while more mechanistic studies are necessary to confirm these outcomes in humans, the available scientific literature appears to suggest that these compounds could be considered an effective nutritional strategy to improve exercise performance.
辣椒素和辣椒素（CAP）是主要存在于辣椒和其他辛辣食物中的天然物质，它们在口腔、胃和小肠中激动瞬时受体电位香草素-1。几项研究表明，CAP 是一种潜在的抗肥胖剂，并在啮齿动物和人类中表现出镇痛作用。然而，关于 CAP 对身体运动表现的影响及其作用机制，尚无科学共识。
本系统评价旨在更好地阐明 CAP 化合物作为运动补剂的作用，并讨论这种补充剂可能增强耐力表现和肌肉力量的潜在作用机制。
在综述中纳入的 22 项研究中，有 14 项研究了辣椒素或辣椒素化合物对动物耐力和抗阻运动表现的影响，其中 9 项研究显示出对运动表现的有益影响。在人类中，纳入了 8 项研究：3 项研究显示出急性耐力运动的显著益处，2 项研究显示出与安慰剂相比抗阻运动表现的益处。因此，虽然需要更多的机制研究来证实这些结果在人类中的有效性，但现有科学文献似乎表明，这些化合物可以被视为一种有效的营养策略，以提高运动表现。
