血清 2019-nCoV IgM/IgG 动态变化与患者出院后 6 个月内免疫力的关系。

Relationship between the dynamic changes of serum 2019-nCoV IgM/IgG and patient immunity after 6 month hospital discharge.

机构信息

Department of Novel Coronavirus Pneumonia Rehabilitation Clinic, Hubei University of Chinese Medicine Affiliated Hubei Hospital of Chinese Medicine, 856 Hao, Luoyu Road, Hongshan, Wuhan, 430070, People's Republic of China.

出版信息

Inflamm Res. 2021 Feb;70(2):241-247. doi: 10.1007/s00011-020-01429-8. Epub 2021 Jan 1.

DOI:10.1007/s00011-020-01429-8

PMID:33385239

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7775635/

Abstract

OBJECTIVES

To investigate the relationship between the dynamic changes of serum 2019-nCoV IgM/IgG and immunity alteration for patients after 6-month hospital discharge.

METHODS

One IgM(+) and IgG(-), 32 IgM(+) and IgG(+), 38 IgM(-) and IgG(+), and 40 IgM(-) and IgG(-) patients were included. Demographic data were collected. IgM and IgG antibodies, hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and lymphocyte subsets in serum were determined at weeks 0, 2 and 4.

RESULTS

The hs-CRP and IL-6 levels of all patients were within the normal ranges. The number of patients with all lymphocyte subset testing items within normal ranges was 12/110 (10.9%) at week 0, 15/110 (13.6%) at week 2 and 18/110 (16.4%) at week 4. The percentages of CD8 + cells, NK cells and B lymphocytes in the IgM(+) and IgG(+) group were quite different from those in the IgM(-) and IgG(+) group and the IgM(-) and IgG(-) group, with much higher percentages of CD8 + cells and much lower percentages of NK cells and B lymphocytes at weeks 0, 2 and 4. Twelve IgM(+) patients in the IgM(+) and IgG(+) group converted to IgM(-), and the percentages of NK cells and B lymphocytes in these patients were significantly increased at week 4.

CONCLUSIONS

The changes of serum IgM and IgG are closely related to immunity in patients in the recovery stage. However, immunity does not recover when the patients test negative for these antibodies.

摘要

目的

探讨血清 2019 型新型冠状病毒（2019-nCoV）IgM/IgG 动态变化与患者出院后 6 个月免疫改变的关系。

方法

纳入 1 例 IgM(+)、IgG(-)，32 例 IgM(+)、IgG(+)，38 例 IgM(-)、IgG(+)和 40 例 IgM(-)、IgG(-)患者。收集患者的人口学资料。于 0、2、4 周检测血清 IgM、IgG 抗体、超敏 C 反应蛋白（hs-CRP）、白细胞介素 6（IL-6）和淋巴细胞亚群。

结果

所有患者 hs-CRP 和 IL-6 水平均在正常范围内。在 0 周、2 周和 4 周时，所有淋巴细胞亚群检测项目均在正常范围内的患者分别为 12/110（10.9%）、15/110（13.6%）和 18/110（16.4%）。在 IgM(+)和 IgG(+)组中，CD8+细胞、NK 细胞和 B 淋巴细胞的百分比与 IgM(-)和 IgG(+)组以及 IgM(-)和 IgG(-)组有很大不同，在 0、2 和 4 周时，CD8+细胞的百分比明显更高，NK 细胞和 B 淋巴细胞的百分比明显更低。在 IgM(+)和 IgG(+)组中，12 例 IgM(+)患者转为 IgM(-)，这些患者在第 4 周时 NK 细胞和 B 淋巴细胞的百分比显著增加。