Gaches J, Supino-Viterbo V, Foncin J F
Acta Neurol Belg. 1977 Jul-Aug;77(4):202-12.
Serial EEG studies and full neuropathological investigations (optic and electronic microscopy of biopsy and necropsy material) were carried out on two patients: 1. A 68-year-old man: development in two and a half months of Creutzfeldt-Jakob's disease signalled by early clinical and EEG changes and confirmed by associated spongiosis of the triad characteristic of Alzheimer's disease, which was unexpected in this case. 2. A 43-year-old man: first phase of four years of progressive deterioration, followed by an encephalopathic syndrome with myoclonus developing in twelve months. The serial EEG studies showed discontinuous periodic paroxystic activity from the start of the second phase of the disease, although the first biopsy still showed nothing but the signs of Alzheimer's disease. A fortnight later, a second biopsy revealed ultrastructural microspongiosis. Examination of necropsy material confirmed the extensive association of the characteristic images of the two processes. On the basis of these two case studies and some similar cases published in the literature, the authors discuss the possible etiological links between these two diseases and stress the importance of the EEG and cerebral biopsy for the purposes of differential diagnosis. (Acta neurol. belg., 1977, 77, 202-212).
对两名患者进行了系列脑电图研究和全面的神经病理学检查（对活检和尸检材料进行光学和电子显微镜检查）：1. 一名68岁男性：在两个半月内出现克雅氏病，早期临床和脑电图变化提示该病，并经阿尔茨海默病三联征相关海绵状改变证实，这种情况在此病例中出乎意料。2. 一名43岁男性：病程四年，最初是进行性恶化阶段，随后在十二个月内发展为伴有肌阵挛的脑病综合征。系列脑电图研究显示，从疾病第二阶段开始出现不连续的周期性阵发活动，尽管首次活检仅显示阿尔茨海默病的迹象。两周后，第二次活检显示超微结构微海绵状改变。尸检材料检查证实了这两种病变特征性图像的广泛关联。基于这两个病例研究以及文献中发表的一些类似病例，作者讨论了这两种疾病之间可能的病因学联系，并强调脑电图和脑活检在鉴别诊断中的重要性。（《比利时神经学学报》，1977年，77卷，202 - 212页）
